Great work !!

How do cell states contribute to the aberrant homeostasis of a tumor tissue? We propose a functional classification as Drivers, Passengers, and Trailers⁦⁩. Fun Xmas project w/ Michela & Chris ⁦MarineLab.🙏 ⁦Elizabeth McKenna⁩ & ⁦Cancer Discovery⁩! aacrjournals.org/cancerdiscover…

Excited to share this work on feasibility of ecDNA oncogene detection from clinical grade GBM samples using WGS. Huge thanks to team and mentors! Charles Swanton Mischel Lab The Crick Annals of Oncology

I’m hosting the 12th international pediatric renal tumor biology symposium at MSK in NYC on June 5-7 with Alex Kentsis MD, PhD and the Children’s Oncology Group & SIOP International kidney tumor group leads; #Wilms #Rhabdoid #RCC ; Free registration and abstract submission until April 1 here:
msk.org/PedsRenalSympo…

Our paper 'Control of cell proliferation by memories of mitosis' is out Science Magazine. We show that cells can detect and memorize defects in mitosis to eliminate potentially damaged cells. OIST Franz Meitinger Oegema/Desai Labs science.org/doi/10.1126/sc…

The first of hopefully many companies developing ecDNA-directed therapies is public ! 👏🏻👏🏻

Just in time for #HumpDay : Our study Targeting DCAF5 suppresses #SMARCB1 -mutant #cancer via stabilizing SWI/SNF is online now in nature. Congratulations 🎉 to co-first authors Sandi-Radko-Juettner and Hong Yue and all co-authors on this story! 1/
nature.com/articles/s4158…

Great work !!👏🏻👏🏻👏🏻

From the March issue—
Passenger Gene Co-Amplifications Create Collateral Therapeutic Vulnerabilities in Cancer, by Yi Bei, Anton Henssen, Jan Dörr et al.
bit.ly/439VhAW
VomLaborInDiePraxis Charité - Universitätsmedizin Berlin Max Delbrück Center Berlin Institute of Health

nature alert! Our recent paper on the 'default states' of the yeast and mouse genomes. Kudos Brendan Camellato Ran Brosh Jef Boeke and the entire Dark Matter Project team!
nature.com/articles/s4158…

On my way to London . Very excited to hear about the new Cancer Grand Challenges teams tomorrow. The funding of eDyNAmiC team led by Mischel Lab has been a true game changer for the ecDNA field!

Fantastic work Manx Neurobiologist and team !! Science Magazine

science.org/doi/10.1126/sc…

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Beautiful review article on ecDNA in Nature Reviews Cancer by Howard Chang Mischel Lab !!

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nature.com/articles/s4156…

Fantastic news for students Albert Einstein College of Medicine - Official !!

February is #OesophagealCancerAwarenessMonth .

We recently caught up with DaveChuter@OGcancersupport, who is a Patient Advocate on #CancerGrandChallenges team eDyNAmic and an oesophageal cancer survivor ⤵️

Learn more about eDyNAmic: bit.ly/4bPT3eb

👏🏻👏🏻👇🏻👇🏻

🔥🔥👇🏻👇🏻ecDNA !!

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Great work by @mattG_jones and Vineet Bafna team eDyNAmiC Cancer Grand Challenges ! 👏🏻👏🏻
I hope that CoRAL as well as Decoil by Mădălina Giurgiu will be useful tools to study ecDNA in the future !

Very happy for Heathcliff Dorado Garcia ⁩ who is defending his PhD thesis today !! 👏🏻👏🏻👏🏻