María Méndez Pérez Sanofi with an unusual example of structure-based design: custom-build binders to albumin for generating novel long-acting variants of insulin to treat diabetes. #EFMCASMC23 EFMC

Third lecture of the morning from Dr Daniel Oehlrich from @JanssenBelgium on the phenotypic screen to NLRP3 lead. #EFMCASMC23

🔬 Join the 3rd Munich-Leiden Virtual ChemBio Talks! 🗓️ September 26, 2023 💻 Virtual Event 🔗 events.bizzabo.com/485752/home Register for FREE now! #MunichLeidenChemBio #VirtualEvent

Today our preprint on the development of a synthesis tag (SynTag) for chemical protein synthesis came out on ChemRxiv: chemrxiv.org/engage/chemrxi… 🥳 Hartrampf Lab @elysetwilliams Aliénor Jeandin UZH Chemistry

#SAMURI is a new #ribozyme for RNA-catalyzed labeling of RNA. It uses a new cell-permeable SAM analogue and generates a novel propargylated nucleotide in RNA. Check out the full story doi.org/10.1038/s41557… rclcu.be/dlcxN

Christophe Nitsche now giving the RSC lecture at #EFMCASMC23. Read his recent papers for free: SARS-CoV-2 Proteases: doi.org/10.1002/cbic.2… (ChemBioChem) Bicyclic Peptides: doi.org/10.1002/anie.2… EFMC #medchem #chembio #pharma #drugdiscovery

Deciphering the Role of the Ser-Phosphorylation Pattern on the DNA-Binding Activity of Max Transcription Factor Using Chemical Protein Synthesis (Muhammad Jbara and co-workers) Muhammad Jbara, Tel Aviv University, Ariel Afek 💔, Weizmann Institute #AngewandteVIP #openaccess onlinelibrary.wiley.com/doi/10.1002/an…

Unprecedented hydrophobic peptides by incorporation of an SCF3 group either directly to an aromatic amino acid followed by SPPS, or by Trp-selective late functionalization of peptides. See the #JOrgChem article by Jure Gregorc et al pubs.acs.org/doi/10.1021/ac… BioCIS Jernej Iskra

Fantastic work led by Zhou in our group, see below his facile semisynthetic method for fluorescent tools which paved the way for an in-depth understanding of SUMO specificity and revealed some more secrets about my favourite DUBs (USP36 and USP16). Malte Gersch MPI Dortmund J. Am. Chem. Soc.

I am very much looking forward to this virtual event on October 4th and to sharing the screen with Alanna Schepartz, Nina Hartrampf & Herbert Waldmann. Thank you, Christian Adam Olsen, for the invitation. If you are interested, you can register for free!

congresos.unr.edu.ar/sinaqo2023/blo…… XXIV Simposio Nacional de Química Orgánica 5-8 Noviembre 2023 Graciela Mahler #XXIVSINAQO

Validation of a New Methodology to Create Oral Drugs beyond the Rule of 5 for Intracellular Tough Targets | Journal of the American Chemical Society #Lipinski #Ruleof5 #OrallyAvailable #Drugs #Protein #KRAS pubs.acs.org/doi/10.1021/ja…

Dynamic Phosphorus! Our new paper in Angewandte Chemie introduces phosphorus V as exchange center in dynamic covalent cascade processes, simulating molecular walkers to find new ways to enter or prevent entry into cells. onlinelibrary.wiley.com/doi/10.1002/an…

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Another successful result of our unique & fruitful collaboration with AstraZeneca : N-Biphenyl Pyrrolinones & Dibenzofurans as RNA-Binding Protein LIN28 Inhibitors Disrupting the LIN28–Let-7 Interaction | ACS Med. Chem. Lett. - published by Wu lab (CGC) pubs.acs.org/doi/10.1021/ac…

🏆Felicitamos a la Dra. Cecilia Saiz, ganadora del 16º Premio L’Oréal Unesco “Por las Mujeres en la Ciencia” de #Uruguay. Más información: bit.ly/3G8xpD6

#SobreCiencia » Productores exterminan plagas pero también polinizadores con productos tóxicos. 🗣️: “Hay que saber bien cómo funciona el sistema para hacer manejos que minimicen el uso de agroquímicos”, dice Carmen Rossini, co-responsable del Lab. de Ecología Química ..

Paper Alert🚨 @PeterChemBio1 group has developed the first cell active inhibitor of #mRNA deadenylation. Published in Angewandte Chemie congrats to Sunit Pal et al. onlinelibrary.wiley.com/doi/10.1002/an…

BREAKING NEWS The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.