Asymmetric Pd/Organoboron-Catalyzed Site-Selective Carbohydrate Functionalization with Alkoxyallenes Involving Noncovalent Stereocontrol (Charles C. J. Loh and co-workers) MPI Dortmund TU Dortmund #openaccess onlinelibrary.wiley.com/doi/10.1002/an…

Forschende um Stefan Raunser Stefan Raunser und Peter Bieling @peterbieling MPI Dortmund haben erstmals auf molekularer Ebene sichtbar gemacht, wie Formine an die Enden von Aktinfilamenten binden.
science.org/doi/10.1126/sc…

Bild: MPI Dortmund

'One Ring to rule them all': Researchers from the groups of @peterbieling & Stefan Raunser Max Planck Society unveil at the molecular level how ring-like formin proteins promote actin filament growth in cells.

➡️mpi-dortmund.mpg.de/en/news/how-ac…

1/ A new paper from PhD student Marius Hedtfeld tests in vitro phase separation assays as predictors of localisation in cell compartments.

authors.elsevier.com/sd/article/S10…

We explain why homotypic or simple heterotypic LLPS assay are unlikely to predict macromolecular localization...

Curious about the molecular mechanism of #actin elongation by #formins ?
Then check out our latest work in Science Magazine!

This was possible due to outstanding team effort. Big thanks to co-first author Wout Oosterheert, Bieling lab and @intein

MPI Dortmund science.org/doi/10.1126/sc…

Our latest work on #actin assembly is now online Science Magazine!

We show how #formins bind and move with the growing barbed end of F-actin.

Awesome collab. between Stefan Raunser and Bieling labs MPI Dortmund, and big thanks to co-first author Micaela Boiero Sanders

science.org/doi/10.1126/sc…

Chemists in Dortmund have identified the first inhibitors of the cancer-related RNA-modifier METTL16 and have thus taken a first step towards new therapeutic options #RNAmedicine #RNAtherapeutics

➡️mpi-dortmund.mpg.de/news/a-promisi…

My team announced Thermo Fisher's new Hydra Bio Plasma-FIB.

Thanks to Dr. Stefan Raunser / Stefan Raunser from MPI Dortmund for sharing in our excitement! bit.ly/3PYtspV

Cryo-EM structure of Slo1 with the auxiliary γ1 subunit suggests mechanism of depolarization-independent activation.

Redhardt et al. 2023, From Raisch lab Tobias Raisch MPI Dortmund

bioRxiv doi.org/10.1101/2023.1…
peer reviewed by Review Commons eeb.embo.org/doi/10.1101/20….

Job offer for a computational postdoc in a collaboration between me and Sidney Becker at the MPI Dortmund (Max Planck Institute for Molecular Physiology Dortmund). The project is very exciting from both the algorithmic and the molecular perspective! mpg.de/21758900/a-com…

Harnessing Multistep Chalcogen Bonding Activation in the α-Stereoselective Synthesis of Iminoglycosides | Journal of the American Chemical Society -Published by the Loh Group in J. Am. Chem. Soc. #carbohydrates #organicsynthesis #Chemistry pubs.acs.org/doi/10.1021/ja…

Harnessing Multistep Chalcogen Bonding Activation in the α-Stereoselective Synthesis of Iminoglycosides Journal of the American Chemical Society MPI Dortmund TU Dortmund Total Synthesis and Methodology Highlights #ChalcogenBonding @AlphaSelective #Iminoglycosides #Anomer #Carbohydrate pubs.acs.org/doi/10.1021/ja…

The Tobias Raisch group together with Stefan Raunser has solved the #cryoEM structure of the Slo1 potassium channel and suggest a novel activation mechanism of voltage-gated ion channels!
Congrats to Tobi on his first last author paper!
febs.onlinelibrary.wiley.com/doi/10.1002/18…

Great work by Nianzhe He and Laura Depta +collaborator Sonja Sievers MPI Dortmund! This paper was published in celebration of Georg Winter Tetrahedron Young Investigator Award - a true visionary in targeted protein degradation, as well as a great collaborator! 2/3

Discovery of the sEH Inhibitor Epoxykynin as a Potent Kynurenine Pathway Modulator - new publication by the Waldmann group in Journal of Medicinal Chemistry #chemicalbiology pubs.acs.org/doi/10.1021/ac…

🔓Don't miss this #OpenAccess work from Peter 't Hart and colleagues on the investigation into two binding sites of WDR5 in relation to lncRNA binding and expression‼⬇

pubs.rsc.org/en/Content/Art…

📍 MPI Dortmund

Congrats Soumitra Polley Tobias Raisch and co-authors for this paper nature.com/articles/s4159… describing structure and function of the human outer kinetochore

Congrats also to Stanislau Yatskevich David Barford and co-workers for nature.com/articles/s4159…

And thank you for co-submitting!

How time flies: 10 years ago our group published the first research article, and it were actually two in the same issue Angewandte Chemie
doi.org/10.1002/anie.2… with Christian Ottmann
doi.org/10.1002/anie.2… with Herbert Waldmann MPI Dortmund
Big thanks to the talented & dedicated group!!!

Check out our latest work on the epigenetic inheritance of centromeres: biorxiv.org/content/10.110…
We demonstrate that PLK1 unlocks a conformational change of MIS18α to license the recruitment of HJURP in early G1 phase.
Delighted to see our findings reproduced by the JP Lab !

Yesterday mkw.nrw minister Ina Brandes visited us and gained insight into our research 'The MPI conducts important #basicresearch , for example to better understand the function of our heart and thus make a decisive contribution to our health'