¿Qué está pasando en Osasunbidea?
He dedicado un tiempo a analizar lo ocurrido en los últimos 10 años.
Las conclusiones son muy duras, muy deprimentes. Dejan en un lugar oscuro a la sanidad pública.
Va hilo.

PRNRP tumours typically exhibit a papillary architecture, but they have a different pattern of cell polarity compared to other papillary renal tumors. The identification of this subtype is crucial for accurate diagnosis and appropriate management! #gupath

#twoforoneseries radical nephrectomy☝🏼well-circumscribed, variegated yellow-orange to red-brown, hemorrhagic mass
✌🏼incidental, irregular gray to yellow to slightly orange lesions (>15) throughout the kidney, ranging from minute to 0.8 cm in size

New Article: Recent Advances in Genitourinary Tumors Updates From the 5th Edition of the World Health Organization Blue Book Series from Riddle et al
doi.org/10.5858/arpa.2…

Great review article on urethral tumors just published in Dec issue of Virchows Archiv European Society of Pathology (ESP) by Drs Cimadamore, Lopez-Beltran, and Montironi. Free to download:
rdcu.be/ds7Ne

Hi #pathology friends,

Anyone up for a #PulmPath #NatPathPuzzler ? Excited to share this one.

Lung nodule. Adult. No prior history. No tricks. Sent to us as a consult asking: what is this??

Splenic marginal zone lymphoma's (SMZL) histologic transformation into a more aggressive process, dare I say diffuse large B-cell lymphoma, occurs in 10-15% of cases➡️
ashpublications.org/blood/article/…

Below pictures 1 & 2 illustrate a SMZL case at initial presentation, involving both the…

🌠🌠Unusual combination of findings: flat urothelial carcinoma in situ in a background of nephrogenic metaplasia #gupath #bladdercancer

Note: cuboidal & hobnail nephrogenic metaplasia (upper R), contiguity of two components (L) & cytologic disorder in CIS (lower R)

Our review article is now available online
GU Pathology Society (GUPS) Daniel Berney International Society of Urological Pathology

Contemporary Updates on Sex Cord–stromal Tumors of the... : Advances in Anatomic Pathology journals.lww.com/anatomicpathol…

New in #HumPathol : TRPS1 expression in primary and metastatic prostatic adenocarcinoma, muscle invasive bladder urothelial carcinoma, and breast carcinoma: Is TRPS1 truly specific and sensitive for a breast primary? sciencedirect.com/science/articl… #pathology #PathTwitter #breastpath

This study reviewed a large consecutive cohort of kidney tumors suspicious for rare MiTF family altered renal cell carcinoma (MiTF-RCC) diagnosed in a tertiary care institution over 8 years. Read it here: bit.ly/3sHiBZ0

Renal medullary carcinoma usually presents with metastasis. Located in the medullary region shows tubulopapillary, cords or solid sheets of cells w/ high nuclear grade and eosinophilic cytoplasm. Neutrophilic infiltration is characteristic. #gupath

Amyloid spicules on silver stain in a classic case of AL Amyloidosis. #Renalpathology #Amyloid Rachna Khera Alok Sharma Sanjeev Sethi Jonathan Zuckerman MD PhD Renal Pathology Society Preethi Sekar

Our manuscript has been accepted at AJPA The American Journal of Pathology.

We were surprised that a marker primarily associated with aggressive B-cell lymphomas (PLK1) is also expressed in the LP-cells (NLPHD).

sciencedirect.com/science/articl…

🩸CD138-negative Plasmablastic lymphoma is a very rare variant that seems to occur much more
frequently as extraoral lesions, most commonly presenting as
lymphadenopathies followed by gastrointestinal lesions

🩸The extraoral lesions tend to have lower HIV and EBV infection rates…

#GUpath

Indeed! In part, this is because the overall rate of metastasis for lung carcinoids is so much lower. Here is from our study: PMID 30923345. Most notable difference is for bone & brain – these are among top sites for lung carcinoids but rare for other NETs. Much to learn here!

An incredibly challenging case of ALK-rearranged poorly differentiated lung adenocarcinoma with diffuse CD30 positivity, mimicking ALK-rearranged Anaplastic Large Cell Lymphoma, first authored by future #hemepath 🌟Giby V. George, MD ➡️onlinelibrary.wiley.com/doi/10.1111/hi… #lymsm Histopathology

1. Carcinoid tumors are usually TTF-1 neg or show weak, focal TTF-1 staining

See PMID 21043816 by Natasha Rekhtman MD PhD

2. When positive, TTF-1 is a good indicator of lung origin in carcinoids (but not in small cell carcinomas!)

cystectomy done for recurrent pT1 papillary urothelial carcinoma

➡️great #GUpath demonstration of 'post-operative spindle cell nodule'

many synonyms, including pseudosarcomatous myofibroblastic proliferation, inflammatory myofibroblastic tumor (IMT, often ALK+)