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Top 5 SARS-CoV-2 lineages in Canada for July 2024: KP.3.1.1 (13.27%) KP.3 (12.24%) LB.1 (8.73%) KP.3.2.3 (7.71%) KP.3.1 (7.6%) Source: GISAID

Characterizing the significance and response to the current US Covid wave A new Ground Truths analysis (link in profile) Thanks JWeiland for the modeling work and graph below

How the brain cleans itself during deep sleep go.nature.com/3Pt6yGH

Glymphatics, sleep, and brain health. A very interesting read erictopol.substack.com/p/our-sleep-br…

How Our Gut Microbiome Can Drive Sugar Cravings, by Eric Topol open.substack.com/pub/erictopol/…

Retraction rates have been increasing by the thousands each year. nature.com/articles/d4158…

Interesting article on AI performance at citing scientific publications: cjr.org/tow_center/we-…

Ontario is currently experiencing a measles outbreak, with the vast majority of cases occurring in unvaccinated individuals who were eligible to receive the vaccine. The measles vaccine is safe, free, widely available, and very effective.

Sending support to our neighbors in the US during these challenging times. So sorry to hear about the job cuts at major universities like Johns Hopkins. cnn.com/2025/03/13/pol…

Changes in brain myelin content among marathon runners “This study offers the striking observation that extreme exercise has a profound effect in the brain that is reflected in reversible structural alterations" Nature Metabolism nature.com/articles/s4225… nature.com/articles/s4225…

Eating a diet high in specific types of nutrients is associated with improved physical and mental health in older age, according to a study in Nature Medicine. go.nature.com/4kSow3T

Our NIH grant to discover coronavirus antiviral meds was terminated today. With this grant, we had developed a better SARSCoV2 inhibitor than Paxlovid, and we recently discovered an improved drug that looks better than Pfizer's own second-generation inhibitor.

Ontario is reporting 557 cases of measles so far in 2025. We had 64 cases for all of 2024.

nature.com/articles/s4158…

open.substack.com/pub/erictopol/…

NEW PAPER: The Alzheimer's predisposition gene variant, ApoE4, decreases levels of SIRT1, which can be rescued by DDL-218, a molecule that binds to to the SIRT1 promoter & improves memory in mice🐁 nature.com/articles/s4159…

May the 4th be with you... lol!

wsj.com/us-news/educat…

cbc.ca/news/canada/em…

Interesting paper on mid-life risk factors—specifically focusing on hypertension, smoking, BMI, cholesterol, and diabetes. nejm.org/doi/10.1056/NE…