Neoantigen T-Cell Receptor Gene Therapy in Pancreatic Cancer | ⁦NEJM⁩ In a case of refractory pancreatic cancer, genetically engineered T cells against the KRAS driver mutation achieved substantial tumor regression! nejm.org/doi/full/10.10… nejm.org/doi/full/10.10…

In contrast to cytotoxic immune cells, CD4+ Th2 cells block cancer development by forcing the tumor cells into terminal differentiation. Fundamental immune mechanism with implications for cancer immunoprevention and therapy #cancerimmunology #breastcancer bit.ly/3NQTnMH

I am happy to share our recent review on ‚The circadian immune system’. science.org/doi/10.1126/sc…

1/ In Science Immunology we report that about 25% of vaccinated patients with critical C-19 pneumonia and a normal Ab response to the vaccine have high levels of auto-Abs to type I IFN (science.org/doi/10.1126/sc…).

Presumably this will now be known as the Freddy Krueger Model of metastasis. Fascinating (and terrifying) temporal regulation of CTCs. nature.com/articles/s4158…

Very happy to share our most recent manuscript on #cardioimmunology!!! Thank you to my lab, our fantastic collaborators Jen Davis Darrian Bugg, PhD @uw & Tufts School of Medicine & to Vesna Todorović Nature Cardiovascular Research for excellent editorial handling. nature.com/articles/s4416…

Very happy to share our study describing a new lineage of RORgt+ antigen presenting cells – Thetis cells – that instruct Treg differentiation and tolerance to gut microbes during early life! nature.com/articles/s4158… Brilliant teamwork led by @BlossomAkagbosu and @ZTayyebi 🧵 1/

Nicolyn Charlot _The Journal of Negative Results_ is long overdue.

Excited to share our work on STING-mediated tumor immune escape mechanism nature. Thanks much for my mentor #JennyTing’s support @ting_lab_unc and our collaborate team members! Pylayeva-Gupta lab #RahulMirlekar UNC Lineberger nature.com/articles/s4158…

Pleasure working with Romagnani Lab on this Nature News & Views article, highlighting 3 exciting recent nature papers which shed new light on how gut Tregs are induced by RORgt+ APCs. How regulatory T cells are primed to aid tolerance of gut bacteria nature.com/articles/d4158…

I’m thrilled to share our paper published online now nature. We have developed a new tool as an addition to the existing arsenal to tackle functional redundancy in group 2 innate lymphoid cells in neuropeptide-modulated intestinal inflammation. nature.com/articles/s4158…

Finally, two papers out within a day of each other from the Susan Bullman and CJohnstonLab relating to the intratumoral microbiota, today in nature (doi.org/10.1038/s41586…) and yesterday in Cell Reports (doi.org/10.1016/j.celr…). 🧵below to those interested!

Thrilled to kick off the holiday season with a new paper from the lab! Out in Nature Immunology today, we explore an unexpected function of terminally exhausted T cells and their contribution to the immunosuppressive tumor microenvironment. 🧵 1/ nature.com/articles/s4159…

Nice way to end 2022! Congrats Clara Taffoni, Johanna Marines and our many co-authors! DNA damage repair kinase DNA‐PK and cGAS synergize to induce cancer‐related inflammation in glioblastoma embopress.org/doi/10.15252/e…

Eric Burnett, MD Santa owes everyone a copy of Janeway’s has been my conclusion from all of this

cGAS evolution, IFN and cancer, oh my!. Our new study describes the ways cGAS detects self DNA and drives IFN responses in cancer. Mouse and human and chimp cGAS all behave differently. Preclinical implications abound. science.org/doi/10.1126/sc…

#LocationLocationLocation! Irvine &co show ⁦Science Magazine⁩ that antigen degradation is driven by spatially compartmentalized proteolysis in the lymph nodes & that low protease activity in B cell follicles allows efficient antibody production! science.org/doi/10.1126/sc…

Confused by the good and evil sides of DNA sensing in tumours? Check out our review on STING signalling in cancer - written by North West Cancer Research-funded PhD student Otto Wheeler for #Essays in Biochemistry Portland Press. doi.org/10.1042/EBC202…

Our lab's first preprint is up! We identify a trojan horse RNA virus, A. odysseus, hiding in the human-infecting parasite, T. gondii. A crazy story; this virus could explain why the 1994 Victoria, BC toxoplasmosis outbreak was so hypervirulent. 👉 biorxiv.org/content/10.110… 👈