I’d been holding onto this news for about a month, so I could celebrate with all my #APPCN Match friends today :) I’m excited to announce, I’ll be heading to Harvard Partners Consortium to complete my postdoctoral training for the next two years—Boston, here I come!

Hippocampal spatial representations exhibit a hyperbolic geometry that expands with experience | Nature Neuroscience nature.com/articles/s4159…

What if you could remove APOE4, the most important genetic risk factor for Alzheimer's disease, from the brain? They did nature.com/articles/s4358… Nature Aging by Gladstone Institutes @justsaysinmice

De Leo et al. report that ascending cholinergic and noradrenergic inputs that converge to the hippocampus to regulate different cognitive domains functionally interact and can efficiently compensate for each other when disrupted. bit.ly/3Z1yofZ

Excited to announce I passed my dissertation defense today :) thankful to my NLAD team without whom I couldn’t have possibly made it to this point @ezgammada Isabelle Avildsen @melpocsai Vivian Chu NSFoldi

Hrybouski et al. report an inverted 'U-shaped' functional connectivity pattern in Alzheimer's disease, with elevated connectivity during the preclinical stage, particularly in areas associated with early tau pathology. PICSL Stan Hrybouski tinyurl.com/5xfn9565

Amyloid ≠ Alzheimer Alzheimer ≠ dementia Aggressive lobbying ≠ good public health decision Even if I support expanded access to Amyloid PET, the caveats and nuances make this a challenging tool to use properly.

First whole-genome sequencing of progressive supranuclear palsy nets six known and six new risk loci. APOE2 was among them; curiously, it seems to increase the odds of PSP. Penn UCLA @LMU_Uniklinikum Mayo Clinic ow.ly/MtjM50Qzpoi

Please re-Tweet to raise awareness: When people with #dementia forget, we can help them remember. (image: Tony Husband Cartoon Archive) #Alzheimers #kindness

Thanks, Lea T. Grinberg, M.D, Ph.D, for the dementia infographic. The European Consensus paper by Giovanni Frisoni et al. includes an infographic on biomarkers for an etiological diagnosis in older persons with MCI and mild dementia. Note that EEG appears :-) @ElectrophysPIA IFCN and its Clinical Neurophysiology journals

Statin Initiation and Risk of Incident Alzheimer Disease and Cognitive Decline in Genetically Susceptible Older Adults. Fascinating study I look forward to replication evidence. Seems as though statins convert APOE4 risk of AD to reference genotypes risk. neurology.org/doi/10.1212/WN…

Discovery could launch new types of drugs to prevent, treat the disease cuimc.columbia.edu/news/newly-fou…

Should APOE ε4/ε4 be considered a genetic form of AD? Just published at Nature Medicine. "By age 65, nearly all had abnormal amyloid levels in cerebrospinal fluid, and 75% had positive amyloid scans, with the prevalence of these markers increasing with age, indicating

Plasma p‐tau217 identifies cognitively normal older adults who will develop cognitive impairment in a 10‐year window alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…

New manuscript published! ✍️👀 Concept neurons evolve from index neurons through overlapping memories. Check it out here: cell.com/trends/cogniti… 1/15

Spruyt et al. report that even before symptoms appear, tau buildup in early Alzheimer’s disrupts brain networks. EEG shows early small-world disintegration. Please read at: buff.ly/aSlcjZp Laboratory for Cognitive Neurology, KU Leuven @laurespruyt

As biomarker tests for Alzheimer’s disease are increasingly being used in clinical care, there are some key differences to note about biomarkers in clinical care and research: 1️⃣ Clinical amyloid PET scans are not the same as research amyloid PET scans. In clinical practice,

Viewpoint: The APOE4 allele is associated with an increased risk of #Alzheimer disease and earlier onset, but more longitudinal studies with diverse populations are needed to accurately estimate this risk. ja.ma/48nKBUb

I’ve Been a Surgeon for 25 Years—Here’s What I Wish They Told Me in Medical School Medical school taught me anatomy, physiology, and pathology. It taught me how to memorize, how to endure, and how to work longer hours than most people thought possible. What it didn’t teach me