Adam MacLean Lacra Bintu Mitch Guttman USC Stem Cell Max Wilson Next up, Raphael Gottardo Raphael Gottardo 📊🧪🖥️ from EPFL taking us From Transcripts to Cells: Dissecting Sensitivity, Diffusion, and Signal Purity in Xenium Spatial Transcriptomics

And that's a wrap! Thank you to everybody who joined us at #SysBioSC2025! Thanks to the NSF-Simons Cell Fate Center UC Irvine for supporting this meeting. I'm coming away refreshed and inspired. Here's to great science and great community.

Reminder of the talk tomorrow! Join us at 9am PDT at youtube.com/live/IgXqBYQF0…

This is a very cool paper, from labs of Lars Velten and Alejo Rodriguez-Fraticelli, PhD extending the idea of using stochastic CpG methylation sites for clonal tracking to also record "deterministic" CpG sites that provide cell state info. Reveals patterns of HSC aging nature.com/articles/s4158…

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Delighted to have our preprint led by Peng Lyu up: Genetic variation reveals a homeotic long noncoding RNA that modulates human hematopoietic stem cells biorxiv.org/content/10.110… 🧵 below ...

Workshop: Cancer Cell State Trajectories & Heterogeneity Across Space and Time Cancer cells don’t stay the same—they evolve across tissues & time, adapting to therapy and the microenvironment. But how do we uncover these hidden journeys from noisy, sparse single-cell data? Join

This was an amazing summer read; thoroughly recommend. It has changed how I think about the role cells play in creating structures, organs: us. Engaging and approachable, yet also even on topics I know deeply I gained a lot: historical anecdotes & new ideas. Alfonso Martinez Arias

Wow! This paper is a wild ride, it has it all. - development and developmental genes (with new discoveries in some of the best-studied) - human evolution - stem cell self-renewal - intricate mechanisms of gene regulation - leukemia risk Congrats to the team; amazing work.

Trust me, the grown up drivers in this town are scary enough.

Online now! Tumor dynamics & spatial proteomics-informed personalized predictions of growth & response Beyond RECIST: mathematical modeling and Bayesian inference reveal the importance of immune parameters in metastatic breast cancer biorxiv.org/content/10.110…

it me, waiting for you to submit your abstract to mathematical-oncology.org/mathonco25 by Aug 31 (pls RT)

The variability of early mammalian embryos never ceases to amaze me. Here a beautiful work on the emergence of PGCs in the cow from Carly Guiltinan biorxiv.org/content/10.110… But look at the embryo amidst the enormous trophectoderm! Could you find it w/o epiblast markers? #Amazing

Reminder of the talk tomorrow!

Closing the JKTG Foundation meeting is Evanthia Roussos Torres, MD, PhD from Keck School of Medicine of USC giving a beautiful integrated presention on, Understanding the dynamics of the tumor-immune ecosystem to optimize immunotherapy in breast cancer. Cool collaborative work with Adam MacLean!

Join us in Espoo (that's in Finland in case like me you had to check) next year for all things haematopoiesis at #EHAReCon2026... 👉 From cradle to grave: normal and malignant hematopoiesis in young and aged settings March 23-26, 2026 | eha.fyi/ReCon2026_f

👇👇Please be sure to sign up and submit your abstracts for these exciting Keystone Symposia on #Hematopoiesis and #Myeloid Cells! 🗓️ February 24-26, 2026

🙌 Save the date 🙌

I gotta hand it to you #MathOnco25 this place is special.

Really excited for this session at #ASH25 💻🧠🩸!! Please come and join us on Saturday, December 6th, at 4 pm!