Single-Cell Multiomics Is Advancing Cancer Research | Biocompare.com biocompare.com/Editorial-Arti… via Biocompare featuring @DruleyMB_CMO Mission Bio “a single-cell multiomics assay can detect protein and genetic markers in rare leukemia cells.” #leusm #leukemia #MRD

Damn beautiful paper. Hats off to this amazing work!

Heart failure in pts treated for adv Hodgkin. - 2000-2018 (ie recent) - Most ABVD (some eBEACOPP) - 10 comparators per case - 1994 pts, med cum dox 237 mg/m2 - Adj HR: 2.94 - RF: DM, MI, age Anthracycline pose signif long term risk. Great work. Godtfredsen et al. #EHA24

CHIPing Away at Proteomics to Find Correlations with Myeloid Neoplasms | So fun to write this with the talented SueDoughScience #CHIPsm #leusm Clinical Cancer Research aacrjournals.org/clincancerres/…

Available for pre-order: our new 384-well ResolveOME™ Whole Genome and Transcriptome Single-Cell Core Kit. An automated ResolveOME workflow, enabling users to seamlessly generate NGS-ready DNA & RNA libraries from each cell with minimal hands-on time: go.bioskryb.com/l/1010901/2024…

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We are pleased that our analyses on somatic mitochondrial DNA mutations (mosaicism) in normal human cells are published! Great work Jisong An. nature.com/articles/s4158…

CONGRESS | #SOHO2024 Chris Hourigan Fralin Biomedical Research Institute discusses MRD as a surrogate endpoint for clinical trials in #AML, emphasizing the difference between the cases for regulatory and clinical use but noting that there is potential for its use as a surrogate in the future. #AMLsm

My work here is done.

If you’re still at #ASH24, stop by poster #4333 and talk to Katarina Micin about her work on single-cell MRD analysis in #AMLsm! Very proud of her great work and nice poster! #leusm #hematology Sylvester Comprehensive Cancer Center

5,562 proteins were found to have tissue-specific enrichment across 32 human tissues. ◼️ The majority of them (3,088) are enriched at the protein but not RNA level. 🧠 The brain hosts the largest number of proteins that are only enriched at the protein level but not RNA level.

Don't miss out on registering for this awesome conference! Looking forward to presenting our work!

The potency of abnormal genetic fusion in chronic myeloid leukaemia in our latest study nature 👉🏽 nature.com/articles/s4158… This cancer is an oddity - one of the few single genetic “hit” cancers, a short trajectory (few years) from start to diagnosis, and explosive growth.

Love to see this!

Tune in to hear about MRD-directed decision making, CAR T updates, and TRIspecific antibodies!

I'm honored to receive the Pap Corps Endowed Professorship in Leukemia! It's been a great 5 years Sylvester Comprehensive Cancer Center and I am looking forward to what we can achieve together with Pap Corps in the coming years! Thanks to Pap Corps, Susan Dinter, Sally Berenzweig & Stephen D. Nimer, MD!

The final version of our paper on CD123 expression in different genetic subtypes of AML is now online #TargetedTherapies #hemepath #LeuSM onlinelibrary.wiley.com/doi/10.1111/bj… British Journal of Haematology

This is not the usual phylogenetic tree of somatic mutations showing what clonal expansions are present and when they arose in a tissue. It additionally shows which cells within the tissue are affected and how the mutations change those cells. Congrats Dan Landau! Lovely work!

Session 3 focused on targeting clonal hematopoiesis (CH). Adam Mead shared his insights on targeting clonal evolution in myeloid malignancies whereas Benjamin Ebert focused on the role of Tet2 dependencies in CH and hematological malignancies #ESHCONFERENCES #ESHAML2025

Wow!! 🔥🔥 CDK4/6 inhibition prevents selection of #ClonalHematopoiesis with DNA-damage repair mutations after chemotherapy! Awesome presentation from Irenaeus Chan from Kelly Bolton MD PhD lab! #ASH25