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We show how the BORC complex prevents human autoimmune disease by controlling endosomal TLR7 levels; all the way from mechanistic cell biology to human disease! Fantastic achievement of Harshita Mishra and Fabian Hauck’s team. Thanks and congrats to all co-authors.

🎉Excited to share our first piece of work from the Majer Lab Olivia Majer! 📢We describe how #BORC complex regulates #TLR7 degradation and prevents human #lupus. Grateful to all the authors for their contribution! biorxiv.org/content/10.110…

New studies explore how systemic lupus erythematosus pathology develops, revealing how mutations in human UNC93B1 lead to TLR7 hyperactivation and autoimmunity. 📄: scim.ag/5u1 TU Dresden 📄: scim.ag/5u2 Harshita Mishra Olivia Majer Max Planck Institute for Infection Biology

Manche Meldungen machen Mut: Nach einer Studie Max Planck Institute for Infection Biology, die gemeinsam mit @LMU_Uniklinikum entstand, kann eine einzelne Genmutation die Autoimmunerkrankung #Lupus bei Kindern hervorrufen. Ein Ansatzpunkt für neue Therapien -> mpg.de/21372380/lupus… Olivia Majer

New trigger of human #lupus found by the Olivia Majer Lab, Harshita Mishra. Mutations in UNC93B1 disrupt degradative sorting of TLR7 and cause #autoimmunty leading to systemic lupus erythematosus. 📄 Now published in Science Immunology: science.org/doi/10.1126/sc…

🎉 Thrilled to share my research article published in Science Immunology science.org/doi/10.1126/sc… Also, highly grateful for the work being featured in Tagesspiegel tagesspiegel.de/wissen/aggress… Thankful for the efforts of all the co-authors, collaborators and especially Olivia Majer.