Leaky gut raises your cancer risk by 6x. The crazier part? 1 in 3 Americans walk around with it & have no clue it’s deadly. Autoimmunity, brain dysfunction & 40+ diseases come from it... Here’s what kills your gut & how to heal it (based on science):🧵

Excited to share our latest work on dual-modal photoacoustic and fluorescence probes specifically designed for Cu(I) imaging in tumors! #Imaging #Copper #photoacoustic #Cancer

Long-Acting and Stapled GLP-1R/GIPR/GCGR Triple Agonist for the Treatment of Obesity and Atherosclerosis | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/ac…

Depletion of a transcriptional factor ZBTB11 using molecular glue degraders can overcome oxidative-phosphorylation-mediated KRAS inhibitor resistance in pancreatic ductal adenocarcinoma with low acute neurotoxicity nature.com/articles/s4158…

Online now! A method for the detection and enrichment of endogenous cereblon substrates dlvr.it/TMRqjR #chembiol

New online! Clinical metagenomics for diagnosis and surveillance of viral pathogens nature.com/articles/s4157…

GLUTs-Facilitated Targeting BRD4 Degradation in Breast Cancer through Carbohydrate-Conjugated PROTACs | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/ac…

A General Strategy to Develop Highly Sensitive FAPα Fluorescent Probes for Invasive Cancer Detection (Xiao-Bing Zhang and co-workers) #AngewandteVIP • onlinelibrary.wiley.com/doi/10.1002/an…

The gut-brain axis is a bidirectional communication network between the gastrointestinal tract and the central nervous system. This dynamic system integrates neural, endocrine, immune, and metabolic signals, many of which are modulated by the gut microbiota. 🧠 1. Neural Pathway

Tau’s microtubule-binding repeat regions interact with amyloid-β (Aβ) to form hetero-assemblies, which can modify Aβ amyloidogenesis and alleviate Aβ-induced cytotoxicity nature.com/articles/s4158…

Mislocated FMT transplantation could cause the microbiome mismataching & off-targeting dysfunctions ..... interesting discovery ! 🧐🧐👍👍

Interesting system for time-resolved fluorescent proteins..... 👍

How exercise promotes the immune system vs cancer, working through a gut bacteria metabolite cell.com/cell/abstract/…

What happens to an ADC after its infusion? How does it interact with tumor & immune cells, what causes response & resistance? Take a deep dive in the molecular world of ADCs though our last review, led by Alfred Zippelius and published in Nature Reviews Cancer. nature.com/articles/s4156…

Engineered aminoacyl-tRNA synthetase mutants facilitate ultrafast bioorthogonal tagging with multiple noncanonical acids for multiplexed nascent proteome profiling in response to different cues in diverse bacteria nature.com/articles/s4158…

Nobel Prize in Chemistry for Metal-Organic Frameworks (MOFs)! Congratulations to 𝗦𝘂𝘀𝘂𝗺𝘂 𝗞𝗶𝘁𝗮𝗴𝗮𝘄𝗮, 𝗥𝗶𝗰𝗵𝗮𝗿𝗱 𝗥𝗼𝗯𝘀𝗼𝗻, 𝗢𝗺𝗮𝗿 𝗠. 𝗬𝗮𝗴𝗵𝗶. Special greetings to Prof. 𝗞𝗶𝘁𝗮𝗴𝗮𝘄𝗮 & his team iCeMS, Kyoto Univ - International, including my old friend Shuhei Furukawa Group!

Key DNA repair enzyme PARP1 promotes transcriptional restart after DNA damage through PARylating and stabilizing AFF1 by preventing its ubiquitylation by the E3 ligase Siah1 nature.com/articles/s4158…

A hair-growth serum based on plant extracts has noticeable results in less than two months. newscientist.com/article/249909…

#REVIEW 🚨 Antibody–drug conjugates are rapidly expanding in clinical cancer treatment and in preclinical development. In this Review, Thurber&Co highlight the molecular interactions and immune effects driving #ADC efficacy and toxicity. 📖⬇️ bit.ly/4oiSijb

Modular PROTAC/IMiD Bifunctional Molecule Design for the Degradation of Synergistic Targets in the Treatment of Lymphoma | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/ac…