Our new paper from Karolinska Institutet out today in eLife - the journal "Longitudinal trajectories, correlations and mortality associations of nine biological ages across 20-years follow-up". #aging #geroscience doi.org/10.7554/eLife.…

My editorial paper entitled, "No raw data, no science: another possible source of the reproducibility crisis". When I feel the results are too beautiful, I requested raw data before sending it out for review. 40 out of 41 did not send me the right data. molecularbrain.biomedcentral.com/articles/10.11…

Launching in January 2021 and now open for submissions, Nature Aging will publish research from across the basic biology of aging, geriatrics, and gerontology to the impact of aging on society. Visit us online to learn more, register for E-Alerts from launch, and submit research.

On Steve Horvath's exciting new preprint claiming to *reverse* the (epigenetic) age of rats by 54% biorxiv.org/content/10.110…

PGP-UK Health Assessment in support of COVID-19 related research. A Big Thank to our participants who proved themselves again as valuable Citizen Scientists by taking part in the Assessment. pgpukblog.wordpress.com

Many congratulations to D. Afonso Henriques, Ismail Moghul, Dr Amy Webster, Simone Ecker, Javier Herrero 🇪🇺, Stephan Beck and all the PGP-UK team PGP-UK on the publication of GenomeChronicler just out in Fontiers in Genetics! frontiersin.org/articles/10.33…

.Wellcome Genome Campus #PersonalGenomics event w/ stellar keynotes 23andMe Joanna Mountain & Stanford University Michael Snyder, PhD among many other world renown scientists. Privileged to form part of the organising committee for such an amazing #international #conference.

Hope you had a good break & Happy 2021! We are back with more weekly webinars! The first one is by Stephan Beck UCL. Stephan will be speaking on "Connecting Dots for Genomics Medicine" next Tuesday, 12th of Jan at 16.30 GMT join us with the link👉 qmulepigenetics.com/webinars pl share

Using inter-individual variation in TF binding and its downstream effects in primary neutrophils as "nature's perturbation experiment" to interpret the function of immune GWAS SNPs. Our joint work with Nicole Soranzo's team, Biola M. Javierre, Account no longer active nature.com/articles/s4146…

1/11 Thrilled to FINALLY share: 🚨 Elevated in vivo IL-17A activity in human active #TB vs latent/cured TB 🚨 Supports targeting this cytokine axis to reduce disease pathology & transmission. #tuberculosis Paper Science Translational Medicine: bit.ly/3el8M9e Explainer thread:👇

Human immune systems can only be understood by studying diverse human populations. In Nature Methods we call for more inclusive human immunology research rdcu.be/ckLzn

Wow, another amazing epigenetic clock study by Steve Horvath et al. They find that methylation levels, set at birth, predict maximum lifespan in mammals. Genes proximal to methylation sites tend to be associated with development, metabolism. biorxiv.org/content/10.110…

Our open letter about academic whistleblowers like Elisabeth Bik is mentioned in The Guardian by @MelissaLDavey You can find the letter here: osf.io/2awsv/ Scientists co-sign it here: docs.google.com/forms/d/e/1FAI…… The article is here theguardian.com/science/2021/m…

A big day for human genomics! It's also very cool that this is released as a preprint.

So excited to announce our preprint “Epigenetic Patterns in a Complete Human Genome” where we generate the most complete human epigenome analysis to date and uncover novel insights into human centromere epigenetic regulation. A few highlights: biorxiv.org/content/10.110…

GOmeth and GOregion are gene set enrichment methods for DNA methylation data from Jovana Maksimovic, Alicia Oshlack & Belinda Phipson. It takes into account the fact that CpGs on chips are unevenly distributed between genes, &and some CpGs linked to >1 gene genomebiology.biomedcentral.com/articles/10.11…

Stoked to see our paper out today in Nature Cancer! Epigenetic cell state, not genetic variegation, is the principal substrate for bottleneck selection during induction chemotherapy in childhood BCP-ALL. Check it out here rdcu.be/cnL8X UCL Cancer Institute

Virginia Turati Javier Herrero 🇪🇺 Peter Van Loo Simone Ecker D. Afonso Henriques Chuling Ding And what a journey! An extraordinarily thorough and painstaking investigation showing that treatment induced selection in B-ALL acts on #epigenetic, not genetic states. Utmost respect for Virginia Turati. #Cancer

⭐️ONLINE NOW Nature Cancer: "#Chemotherapy induces canalization of cell state in childhood B-cell precursor acute lymphoblastic #leukemia" by Virginia Turati Tariq enver &Co UCL Find it here!👇 go.nature.com/3hHKW8a rdcu.be/cnUJc #CancerTherapy #Chemoresistance

#EWAS of smoking and #epigenetic #age acceleration among Costa Rican adults. Former smokers had consistent age acceleration and we replicated smoking related hits in Latine pop David Rehkopf Simone Ecker Raj Fadadu MD, MS Karen Huen Lisa McEwen Nicole Gladish, PhD Kobor Lab nature.com/articles/s4159…