This week in #MathOnco 168: Artistoo, personalized immunotherapy, single-cell, collective migration, and (finally) math onco conferences! thisweekmathonco.substack.com/p/this-week-in… Cover design by Inge Wortel, designed using #Artistoo.

Huge collab driven by Virginia Turati and the Enver lab providing one of the better proofs I’ve seen so far that preexisting epigenetic cell states are selected for during chemotherapy. Congrats all!

⭐️ONLINE NOW Nature Cancer: "#Chemotherapy induces canalization of cell state in childhood B-cell precursor acute lymphoblastic #leukemia" by Virginia Turati Tariq enver &Co UCL Find it here!👇 go.nature.com/3hHKW8a rdcu.be/cnUJc #CancerTherapy #Chemoresistance

In our latest Nature Cancer paper (rdcu.be/cnL8X), we use different technologies to interrogate BCP-ALL resistant cells, including mFISH, qPCR, bulk RNA, scRNA, low-pass scWGS and DNA methylation arrays on diagnosis, MRD, relapse, PDXs and control chord blood 1/7

Nice to see our work describing the relative contribution of different sources of intratumor heterogeneity to #chemoresistance in BCP-ALL featured in the Research Watch section of Cancer Discovery 👇 cancerdiscovery.aacrjournals.org/content/early/… For the original paper Nature Cancer rdcu.be/cnL8X

Pleased to share our 1st #AndersonLab imaging focussed tool, Mistic: an open-source multiplexed image t-SNE viewer developed by Sandhya Prabhakaran with help from Chandler Gatenbee Mark R-T & Jeffrey West doi.org/10.1101/2021.1…

Excited to share our latest tool, #VALIS Virtual Alignment of pathoLogy Image Series - it’s been years in the making by the talented Chandler Gatenbee! It automatically aligns serial image slices from immunohistochemistry, immunofluorescence & much more. Here’s a cool gif! #AndersonLab

Pleased to announce the release of #AndersonLab latest tool: GATTACA, for base pair resolution mutation tracking in agent-based models like HAL. Developed by Ryan O Schenck for our somatic evolution studies. Here’s a cool gif! biorxiv.org/content/10.110…

Just our in Nature Biotechnology a cool collaboration with Trevor Graham & Darryl Shibata led by Calum Gabbutt with help from Ryan O Schenck & Mark R-T Fluctuating methylation clocks for cell lineage tracing at high temporal resolution in human tissues go.nature.com/3sTqOa8

75 years of research on human diseases in 1 minute

“Already, the United States claims the highest rate of maternal and infant mortality among wealthy nations. Should the court overturn Roe v. Wade, these grim statistics will only get worse,” argued a Nature editorial last month go.nature.com/3QNIrli

Just sent out #MathOnco newsletter issue 216: -evolutionary game theory -continuum resistance -reaction-diffusion -stochastic control -clinical translation Artwork: Virginia Turati 💯

Happy to share the latest #AndersonLab tool developed by Sandhya Prabhakaran Mistic: An open-source multiplexed image t-SNE viewer, cell.com/patterns/fullt… with help from Chandler Gatenbee, Mark R-T & many more! Our 1st publication in Cell Press Patterns.

Fresh preprint! In this work, we study the dynamics of metastatic disease, i.e. changes in the collective systemic burden and in the individual metastases, over cycles of adaptive therapy to infer underlying disease characteristics.

I’m excited to share our recently published manuscript in PNAS on clonal dynamics in the homeostatic epidermis. This paper took a winding course and was the first project that was incorporated into my DPhil. 1/🧵