Check our new preprint on the "Catalytic relevance of quinol anion in biological energy conversion by respiratory complex I" bioRxiv biorxiv.org/content/10.110… . Simulations by Oleksii Zdorevskyi #JohannesLaukkanen. A thread

How do Proteins Perform under Pressure? Haley Moran JHU CBI Stephen Fried JHU teamed up with Richard Gillilan Cornell University Cornell High Energy Synchrotron Source and combined high pressure biophysics & structural proteomics to give us some answers! Out now in PRX Life. 1/3 journals.aps.org/prxlife/abstra…

👏🙌#HPC #supercomputing #AliceRecoque

Do you want to see how big multimeric biosystems are organized and how the effects of mutations propagate and diffuse from monomers to large aggregates? Our bioRxiv reveals these mechanism for Hsp60 and its functional dynamics. biorxiv.org/content/10.110…

Very good review on nucleosome dynamics. wires.onlinelibrary.wiley.com/doi/10.1002/wc…

In the second CACHE challenge, the top performer hailed from a regional university in Brazil. So happy we created an opportunity that allowed her to show her stuff. Brilliant folks are everywhere - they just need a fair shot. conscience.ca/news/cache-cha…

🎉 Results of CACHE Challenge #2 are out! Five top-scoring teams from around the 🌍 used #AI, #CitizenScience, and #OpenSource tools to identify 7 promising hits that could lead to a pan-coronavirus treatment. Dataset is now publicly available to all! conscience.ca/news/cache-cha…

Announcing CACHE2 results! Crowdsourcing and conventional methods did as well as novel ML. Teams started from 4 fragments in the PDB. We tested their predictions and found double-digit µM hits. This is the state-of-the-art. Structural Genomics Consortium (SGC) Conscience bit.ly/4dTPBzO

Kudos to Cheryl Arrowsmith 's amazing biophysics team Structural Genomics Consortium (SGC) who ran the experimental validation. A special shout-out to Oleksandra Herasymenko and Madhushika Silva who led the charge!

Very excited to have taken part in the CACHE2 hit finding challenge. Thank you so much to the organisers and well done to all the participants! We've written up some of our experiences in this blog: cole-group.github.io/2024/09/10/cac… Newcastle Chemistry Sciences at Newcastle

Today, Supervisor Nora Vargas held an emergency press conference claiming the air in South Bay SD is safe. Yesterday, I presented our findings at a presser showing continuous, multi-day measurements of hydrogen sulfide (H2S) well above the CARB ambient hourly standard of 30 ppb (1/8)

This is a serious environmental injustice. The science showing poor air quality (H2S well above ambient standard) validates what the residents have been reporting. In the end, truth will prevail. I am speaking up because people in this area deserve clean air and water NOW. (6/8)

Our latest paper - led by Dhanushka Weerakoon (Nush) helped by Conrado Pedebos, Jan Marzinek & Peter Bond jbc.org/article/S0021-… Journal of Biological Chemistry Polymyxin B1 in the E. coli inner membrane: a complex story of protein and lipopolysaccharide mediated insertion

Cool new preprint from Amgen 🧪🔬🧬 introducing LYMTACs, bifunctional small molecules that target cytosolic proteins to lysosomes biorxiv.org/content/10.110…

The October 1 abstract submission deadline for #bps2025 will be here before you know it! Start working on your abstract today! biophysics.org/2025meeting#/

Awesome lineup of scientists for our annual postdoc Rising Stars Symposium 🙌 Keynote Elizabeth Villa!

Apparently, this tweet was labeled as "adult content". While perplexing, that's technically correct as these fellowships are for adults.

Prof. Adrian Roitberg received the Frank E. Harris Professorship in Theoretical Chemistry. This professorship was made available through the generosity of the estate of Frank E. Harris. Dr. Harris was a member of the dept faculty in the Quantum Theory Project. Congrats!

Out now with PekkurnazLab :) Way to go John Vant and #Howard. nature.com/articles/s4225…

Excited to share our recent simulation study on the main protease of SARS-CoV-2 — preprint on bioRxiv —