Excited to share a short article I wrote describing: Slide-tags - which enables spatial single-nucleus sequencing, allowing us to dive deeper into the complexity of tissue organization. Grateful for the amazing team and support from Fei Chen Lab and Evan Macosko! #ToolsOfTheTrade

Cancer evolution enthusiasts - you might be interested in some new data from our lab on quantifying cell divisions along evolutionary lineages in colorectal and lung cancer, published today in Nature Genetics! If so, some highlights below 👇 nature.com/articles/s4158…

🚨 New paper in nature! 🚨 We’ve mapped the human hypothalamus in unprecedented detail, revealing key differences from mice & unlocking insights into obesity, metabolism & drug development. Meet HYPOMAP—a cellular Google Maps for the brain’s metabolic control centre. 🧵(1/)

Applications are closing on 1 April for our #EBECancer25 course⏰ Our expert trainers and speakers will guide you through how to apply #evolutionary and #ecological knowledge to deepen your #CancerResearch insights🧬 Bursaries available💰 📝Apply now: bit.ly/3WsZspB

Interested in the mysteries surrounding metastasis evolution? This perspective in Nature Reviews Cancer is my best attempt at proposing a framework that could help advance our thinking about the topic. Well. At least it helped advance my own thinking. 😅 nature.com/articles/s4156…

Call for Papers! Genome Research is now encouraging submissions for a Special Issue on The Genetics and Genomics of Somatic Mosaicism, Guest Edited by Drs. Gilad Evrony, Eunjung Alice Lee, and Raheleh Rahbari. tinyurl.com/Call-for-paper… #BOG25 #KSMosaicism25 #MITS25 #somaticmosaicism

New online! Cell-type deconvolution methods for spatial transcriptomics bit.ly/43hY2AT

🚨Preprint Alert!🚨 Cell classification is one of the most difficult tasks in analyzing spatial data. We present CellTune - a powerful toolkit for accelerating biological discovery in spatial proteomics. 📄 biorxiv.org/content/10.110… 👇🧵1/7

Big, beautiful trees!! SMART-PTA for whole-genome+transcriptome on thousand of single cells from the normal human esophagus 🤯 Massively scaling up the power of scWGS to build deep phylogenies and chart somatic evolution from birth throughout life. biorxiv.org/content/10.110…

Call for papers deadline is quickly approaching! More information on the topic of interests can be found here: tinyurl.com/Call-for-paper…. Guest Edited by Drs. Gilad Evrony, Eunjung Alice Lee, and Raheleh Rahbari. #ASHG25 #BOG25 #KSMosaicism25 #MITS25 #somaticmosaicism

If blood has clonal haematopoiesis… sperm should get clonal spermatopoiesis, right? 😉 Two great nature papers shed new light on how mutations drive clonal selection in sperm stem cells: 🧬 Neville et al. 👉 nature.com/articles/s4158… 👨‍👩‍👦 Seplyarskiy et al. 👉

145 families finally get answers about rare conditions that had gone undiagnosed for years. 🧬 By looking more closely at how DNA can rearrange itself, researchers uncovered changes that standard tests often miss. Find out more 👇 sanger.ac.uk/news_item/145-…

Read ‘Complex de novo structural variants are an underestimated cause of rare disorders’ from @SangerInstitute, Genomics England, Cambridge University Hospitals NHS and collaborators in Nature Communications here: nature.com/articles/s4146…

How does the evolution of the cancer epigenome contribute to immune evasion? We investigated this in colorectal cancer, where we found that immune evasion follows a ‘Big Bang’ evolutionary pattern, initiated right at transformation: nature.com/articles/s4158…