04/25/2024, Zheng Lab@OSU, good memories and ready for the new journey.

Please find our new paper regarding the methodology development and chemical proteomic profiling of protein dopaminylation in colorectal cancer cells.

Also, please stay tuned for our recent work regarding the chemical biology tool development and proteomic profiling of novel PTMs in cancer cells. biorxiv.org/content/10.110…

Glad to see our latest mini-review summarizing the current and future research focus of my lab published on BBA-Proteins and Proteomics BBA , which is a collection of '2024 BBA Rising Stars in Biochemistry and Biophysics'. doi.org/10.1016/j.bbap…

HFIP's magic shines again, enabling peptide stapling with alpha-ketoaldehydes through unique imidazolium linkers, outperforming natural “glycation” processes. We proposed HFIP aggregates act as a proton shuttle for efficient deacylative C--C cleavage.

Thank you so much Memorial Sloan Kettering Cancer Center for the shoutout!! So proud to be part of the incredible operation at MSKCC💙

Thank you Sloan Foundation for supporting the David lab research! 👩🏻‍🔬💪🏻

Extremely excited to host Yael David 's fascinating seminar tomorrow! Welcome to Ohio State, Boss Lady!

Excited to share our new preprint describing intracellular ubiquitination of a small molecule, BRD1732, a molecule that has remained a mystery since identification in early 2010s by Enrique Garcia-Rivera, Micah Maetani, Stuart Schreiber and Cigall Kadoch. biorxiv.org/content/10.110…🧵

Glad to see our paper was selected as the Best Review of 2023 by iMeta!

A new probiotic-guided CAR-T platform uses engineered bacteria to infiltrate and produce synthetic antigen targets, enabling CAR-T cells to find, identify, and destroy tumor cells in situ.

Learn more in this #SciencePerspective : scim.ag/52v

A new probiotic-guided CAR-T platform uses engineered bacteria to infiltrate and produce synthetic antigen targets, enabling CAR-T cells to find, identify, and destroy tumor cells in situ.

📄: scim.ag/4vh
#SciencePerspective : scim.ag/4vi

Glad to see our paper in collaboration with Dr. Domenica Scumaci is online today, in which we discussed the links between epigenetics and metabolism as well as the corresponding vulnerabilities to fight cancer. biosignaling.biomedcentral.com/articles/10.11…

Wow! Look at who followed me and liked my tweet! Feeling so excited and honored! Also, looking forward to seeing you Carolyn Bertozzi in SF this Sunday noon! And of course, I need to arrive at Moscone Center 3 hours earlier to grab a seat🤣～ #chemicalbiology #ACSFall2023

Congrats to Shruthi for her 2nd (co)first-author and 10th co-author paper in my lab, published on Cancer Biology & Therapy! In this review, we systematically summarized the role of the #humanmicrobiome in cancer development, diagnosis, and treatment.
tandfonline.com/doi/full/10.10…

Huge Congrats The Maze Lab! So well deserved!

It is me who feels extremely proud of being a David Lab alumnus! I owe my BOSS LADY so much for the generous supports in so many ways. 🥰

Thrilled & honored to share that our lab The Ohio State University Wexner Medical Center The James has been awarded an NIH NIGMS
#R35 #MIRA ! Thankful to all of our lab members, mentors (@David_Lab_MSK), colleagues, and collaborators (@themazelab)! This 5-year grant will support our work on novel histone PTMs!

Our work w/ Aumeier Lab, UNIGE_en and many others EPFL Chemistry & EPFL Life Sciences, out in Nature Chemistry, where we produce tubulins with defined PTMs and demonstrate that polyE primes MTs for detyrosination: nature.com/articles/s4155…; big congrats to 1st authors Eduard and Simon!

Enzymatic Fluoromethylation Enabled by the S-Adenosylmethionine Analog Te-Adenosyl-L-(fluoromethyl)homotellurocysteine

NEW #ASAP by Squire J. Booker, Bo Wang, & co-workers from Penn State Chemistry. Read it here: go.acs.org/5cR

I had a great time at the very first Gordon Research Conferences on Histone and DNA 🧬Modifications! Thanks to the organisers Tatiana Kutateladze and The Muir Lab.
I was finally able to meet former @David_Lab_MSK alumni Qingfei Zheng (with special appearance from Galligan Lab #teamglycation )