🚩 Tranexamic Acid - it's complicated....

➡️It's widely used for treatment & prevention of haemorrhage
➡️It's in the WHO's List of Essential Medicines & recommended in the European Traumatic Haemorrhage guideline (2023)
➡️But is it as efficacious as we think?

🧵 1/17

Patient presents with constipation !!

Labs show hypercalcaemia 😲😲
Blood smear shows 🌸🌸🌸🌸🌸🌸

Diagnosis?
Management?

#MedTwitter

(1/10) Pericardial tamponade is a clinical diagnosis supported by #echo (2D + quantitative). A 🧵of 10 confirmed tamponade cases (by drainage!) starting with obvious and ending with subtle ones that you could easily miss.. some PEARLS along the way 👇 #medtwitter #foamed

as clinical medicine becomes more complex and research grants are harder to secure, the traditional 'triple-threat' is becoming unachievable.

'encouraging mastery across too many domains... can lead to mediocrity, lack of fulfillment, and disorganization'

CodeFusion: A Pre-trained Diffusion Model for Code Generation

abs: arxiv.org/abs/2310.17680

A simple encoder-denoiser-decoder architecture with only 75M parameters trained as a diffusion model is competitive when finetuned on several text-to-code tasks, sometimes even beating

Very interesting thread with great context on how causative correlation of sodium over-correction and Osmotic Demyelination Syndrome has been overemphasised in clinical practice.

TFW I'm looking for some quality reading on secondary hypertension, and then I see Jordy Cohen, MD, MSCE as the senior author and realize I have found the paper I need.

Evaluation and Management of Secondary Hypertension sciencedirect.com/science/articl…

AL Amyloidosis Overview The Intern At Work #MedX #MedEd

If you believe an RCT with P<0.05 for an outcome is strong evidence an intervention works, please read this paper we wrote on Bayesian interpretation of RCTs.

Bottom line: P<0.05 has about 25% chance of intervention not working!

The paper explains why.

link.springer.com/article/10.100…