Do cutting-edge CAR-T-cell therapies cause cancer? What the data say

Regulators have identified 33 cases of cancer linked to this blockbuster treatment.
nature.com/articles/d4158…

This is a great idea!

Safe Inside - Clean The Air have launched a campaign asking everyone to make one short, simple phone call to your local DENTIST or OPTICIAN to ask if they'd be willing to wear a mask and whether they have HEPA air filters.

Think of it a bit like a virtual Flash Mob!

H5N1 Viruses and Vaccines journals.plos.org/plospathogens/…

1. Prof. Jose-Luis Jimenez warned us in 2020 that nose inoculation is a poor way to infect and needs a dose 100,000 higher for the same symptoms as airborne transmission (for flu and smallpox) and that Covid was likely similar.

Astrophysicist and Nobel laureate Subrahmanyan Chandrasekhar used to travel 80 kilometers every week from the Yerkes Observatory to the University of Chicago, where he taught a course attended by only two students. When asked why he spent his time this way, the professor replied…

JusDayDa Interesting problem with the study x.com/lazaruslong13/…

Our latest nature paper is out! We show that transplanting mitochondria into endothelial cells boosts their ability to form blood vessels in ischemic tissues, with mitophagy as the key mechanism. A potential game-changer for vascular cell therapies. nature.com/articles/s4158…

Raj Rajnarayanan U.S. FDA Anyone else notice what piece of information was withheld from this briefing?

No cultured/plaque-assay or egg-grown virus (that’s good)

But what % of Milk had detectable debris?

Was it 20%?
Was it Texas-Kentucky-Nebraska?
More data please

fda.gov/food/alerts-ad…

mynameis6262 1. COVID test wont be able to detect H5N1
2. Many rapid tests available to detect Influenza A (but wont be able to differentiate subtypes; H5 etc)
3. Local Public Health labs have access to authorized CDC PCR test
more info on testing
cdc.gov/flu/profession…

This may end up being a big deal:

Usually LLMs just predict the next token in a sequence, one at a time, but if you have them predict the next several tokens at once you get significantly better performance, faster, and with no added costs. The gains are better for bigger models

This data is insane

LC patients who had worse anxiety, depression etc (COOP chart scores 4 and 5) had higher blood levels of COVID RNAs and lower overall immunometabolism scores

I'll share more on this soon. It's from Johan Van Weyenbergh's group in Belgium

thelancet.com/journals/lanmi…

64Bit Modeling All great questions. None are answered comprehensively in any literature I’ve reviewed.

We do know that platelets remain infected in HIV for some patients but not others. Those whose platelets remain infected have less response to therapy.

I suspect for COVID, the answer is…

A comprehensive review of highly pathogenic avian influenza (HPAI) H5N1: An imminent threat at doorstep sciencedirect.com/science/articl…

“influenza A in wastewater from Amarillo, Texas, were “among highest ever measured,”. Study authors stress no H5N1 outbreaks in cows reported in sewersheds tested.  Instead, they think that dumping of milk likely caused big spikes in H5 virus.” amp.cnn.com/cnn/2024/04/30…

Abatacept, an anti-inflammatory immunomodulating drug used to treat psoriatic arthritis, reduced mortality and showed better recovery in patients hospitalized with severe COVID-19. buff.ly/4bji545

A higher dose may be needed for the highest benefit however.

How thrilling to see this online after 8 years in the works!!!

We showed that #Lyme bacteria
mimic our own“don’t eat me” signal with their P66 protein to hide in plain sight!!! This tricks our SIRPa protein to trigger the breaks on immune clearance!
biorxiv.org/content/10.110…

Can you help save Middlewood time by ordering your repeat prescriptions on the #NHSApp ?

TL;DR: They couldn't reliably infect participants with WT or Delta, even at high doses. It indirectly strengthens the idea that rapid & frequent vaccine updates (protein/mRNA) could lower infection risk significantly while we develop more durable vaccines. nature.com/articles/d4158…

Situation update on monkeypox. 1. The global outbreak is still ongoing. A pandemic preparedness test: this virus is far less transmissible, yet we were not able to stop it from spreading for various reasons. 2. Ongoing and expanding circulation in DRC, with little…