It has been four years since this journey started, but (this chapter at least) has come to an end! Our work on "Chemical generation of checkpoint inhibitory T cell engagers for the treatment of cancer" is now online in Nature Chemistry! nature.com/articles/s4155… 1/9

New bioRxiv from our lab and College of Chemistry grad student Margot Meyers on the discovery of a covalent recruiter for the CUL4A adaptor protein DDB1 for PROTAC applications! biorxiv.org/content/10.110…

Excited to share this work from Christine Isadora Ng! Precise control over protein subcellular localization could have massive implications for gain-of-function therapeutic strategies. We showcase targeted relocalization activating molecules (TRAMs) for rewiring interactomes. (1/n)

New paper from our lab by postdoc Seong Ho (Johnny ) Hong on the discovery of a covalent recruiter against the Cullin adapter protein SKP1 for targeted protein degradation applications! biorxiv.org/content/10.110…

Excited to showcase our new bioRxiv frm postdocs @floraliciaflor & Nafsika Forte on the discovery of covalent degraders of oncogenic transcription factor b-catenin (CTNNB1) via destabilization! College of Chemistry UC Berkeley MCB The Mark Foundation for Cancer Research biorxiv.org/content/10.110…

New bioRxiv from our lab by Qian Shao on a covalent 14-3-3 molecular glue with the transcription factors YAP and TAZ and using this glue as a 14-3-3 recruiter to sequester nuclear neo-substrates into the cytosol! Thanks to #AppleTreePartners & @themarkfdn

The Nitrile Bis-Thiol Bioconjugation Reaction | Journal of the American Chemical Society @vijaychudasama_ UCL Chemistry #Thiol #Nitrile #Bioconjugation pubs.acs.org/doi/10.1021/ja…

Congrats to our postdocs Seong Ho (Johnny) Hong & Anand Divakaran on the discovery of a covalent recruiter against the CUL1 substrate adaptor protein SKP1 that targets a SKP1/substrate receptor interfacing C160 to enable PROTAC applications! College of Chemistry UC Berkeley MCB The Mark Foundation for Cancer Research

Congrats to chembio grad student Melissa Lim and postdoc Eric on their bioRxiv on the discovery of a minimal covalent DCAF16 degradative handle for rational design of linker-less monovalent degraders against not only BRD4 but also several other targets!

Congrats to ⁦Frontier Medicines⁩!!!! So proud of this accomplishment!! Frontier Medicines Announces Oversubscribed $80 Million Series C Financing to Support Progress of Clinical-Stage Pipeline | Frontier Medicine frontiermeds.com/newsroom/press…

Congrats Peter!!!

Congrats to our former grad student and now postdoc Flor Alicia Gowans on her paper on investigating proteome-wide targets and anti-cancer mechanisms of the natural product Ophiobolin A in collaboration with #TomMaimone! College of Chemistry pubs.acs.org/doi/10.1021/ac…

Congrats to Melissa Lim & Thang Do Cong on their ACS Central Science paper on the discovery of a minimal degradative covalent handle that targets DCAF16 for rational design of monovalent degraders! Thanks Novartis Science The Mark Foundation for Cancer Research! College of Chemistry UC Berkeley MCB pubs.acs.org/doi/10.1021/ac…

Excited to have this paper published! Congrats to Flor Alicia Gowans and Nafsika Forte on their J. Am. Chem. Soc. paper on a direct-acting covalent destabilizing degrader against the challenging oncogenic transcription factor beta-catenin! We go from an initial nonspecific and nonpotent hit

Excited to present our newest paper in J. Am. Chem. Soc. by Qian Shao on using a novel covalent molecular glue of 14-3-3 and ER/YAP/TAZ as a 14-3-3 recruiter for targeted protein localization of nuclear neo-substrates into the cytosol as a new induced proximity approach.

Happy to share that we have a new AstraZeneca-linked PhD opportunity available (with Baker Group) in the area of C-terminal cysteine modification to create novel antibody-drug conjugates (ADCs)! Link to apply below, deadline: 28/01/25, UCL Chemistry shorturl.at/wC2sr

Excited to post our latest bioRxiv by Charlotte Zammit, Cory Nadel, Ryan Potts and our group on a covalent destabilizing degrader of AR and AR-V7 in androgen-resistant prostate cancer cells! Great collaboration with Amgen 🧪🔬🧬. biorxiv.org/content/10.110…

New ⁦bioRxiv⁩ from our lab, Maimone lab, & ⁦Novartis Science⁩ on a covalent destabilizing degrader of myc that acts through stereoselective targeting of an IDR C203 in MYC! Congrats to Hannah Rosen & Kelvin Li! biorxiv.org/content/10.110… biorxiv.org/content/10.110…

Excited to highlight our latest bioRxiv by graduate student Lauren Orr on the discovery of a covalent degradative handle that acts through two unique cysteines C173 and C178, on the frequent-hitting E3 ligase DCAF16 that can be used to modularly design monovalent and

Happy to present our latest paper with Ryan Potts & Amgen 🧪🔬🧬 in J. Am. Chem. Soc. by co-first authors Charlotte Zammit & Cory Nadel on the discovery of a direct-acting covalent destabilizing degrader of AR and the undruggable truncation variant of AR, AR-V7, in androgen-independent prostate