Memory genes are enriched in CAR T cells that persist and control tumors in patients. But which transcription factors drive beneficial memory programs?

We answer this in our lab’s first paper in nature led by Alex Doan Kat Mueller, PhD Andy Chen. 1/

nature.com/articles/s4158…

How to pick a problem. Today in Cell. 1/53
cell.com/cell/fulltext/…

Is forgetting a bug or a feature? Can you delay it and remember longer? Our 🥶COOLEST paper to date (and our most poetic abstract…) Show LOVE ❤️and please SHARE! Thread (1/N)👇
biorxiv.org/content/10.110…

Excited to share with you our manuscript describing the endogenous protein La as a mediator of prime editing and the development of our PE7 editor, which can improve prime editing. For more, please check out nature.com/articles/s4158…

Join us for this great conference in August! Great talks, very friendly community. Mammalian Synthetic Biology Workshop, August 6-7, 2024, Boston aiche.org/sbe/conference…

So excited to see our work on 'Profiling the proximal proteome of the activated μ-opioid receptor' using APEX-based proximity labeling and quantitative mass spec published today. It is the result of an amazing team effort!
nature.com/articles/s4158…
#TeamMassSpec #Proteomics #GPCR

New preprint from our lab is up on bioRxiv - a really awesome synthetic genomics paper that Xinyu Lu from the team has been brewing for the last few years. Xinyu Lu biorxiv.org/content/10.110…

Our latest preprint, on T cell receptor (TCR) signaling by condensate nucleation!
This theory + experiment study was led by the brilliant Will White, with Jay Groves College of Chemistry and David Baker Institute for Protein Design and Ariel Ben-Sasson.  (1/n) biorxiv.org/content/10.110…

Follow along for today's session of our workshop 'A Question of Beginnings: Lab Embryos Between Nature and Synthesis.' Join us in-person or online:
Thursday virtual at 4:30pm EST: harvard.zoom.us/j/92365908277

Complete program and in-person registration:
global-observatory.org/embryos

Our paper on functional discovery of protein degradation and stabilization effectors with proteome-scale induced proximity screens is out in its final version! 1/ nature.com/articles/s4158… rdcu.be/dBUju

Delivering and expressing a gene in cells is usually a messy (heterogeneous) process. The messiness interferes with research and applications such as gene therapy.
In two new papers, we introduce a toolbox of synthetic miRNA-based control circuits that enable more precise, gene…

So excited to share Sarah Soliman’s new inducible systems for controlling mESC behavior! Sarah built these systems as a stepping stone to studies of tissue organization, but as our neighboring labs began to make use of these tools we knew it was time to share them with the world!

Today in @Science_Magazine we report the laboratory evolution of compact degrons that enable targeted protein degradation triggered by an otherwise-inert small molecule, a multidisciplinary study that integrates organic chemistry, molecular glues, protein evolution, genome…

Phagocytes write quick reviews of every meal. Turan Tufan Kodi Ravichandran

nature.com/articles/s4158…

We're hiring! We're taking another big leap in using synthetic biology to engineer materials - this time for sustainable food and textiles. In the next few weeks, we've up to 4 postdoc positions opening up. I'd love to hear from anyone interested in joining us this year. Pls RT🔁

Congratulations to Chroma Medicine founder & Twitterless Angelo Lombardo & colleagues on their beautiful study, out today in nature, demonstrating the utility of epigenetic editing to durably silence a gene in vivo.
nature.com/articles/s4158…

PRC2 is reported to bind RNA. Yet, genetic experiments have raised serious questions about their functional relevance. Our paper revisits the biochemical evidence supporting widespread PRC2-RNA interactions and finds that many of these do not occur in vivo.…

Our study is online Molecular Cell! Compared to our preprint (see previous 🧵), we added additional evidence that transcription factor exchange is required to prolong transcriptional burst duration. Thanks reviewers for suggesting this experiment. 1/4 dlvr.it/T2yqrm

Online Now: Transcription factor exchange enables prolonged transcriptional bursts dlvr.it/T2yqrm

Come work with us! Looking for someone passionate about #synbio for sustainable agriculture. Work at
Northwestern CSB with us, Tullman-Ercek Lab Ashty Karim,
Kamat Lab and the center of synbio community!

Details and app: syntheticbiology.northwestern.edu/engage-with-us…