Our work on studying chromatin context-dependent regulation of prime editing is officially out on @Cell.
cell.com/cell/fulltext/…

Our latest, by the brilliant Xiaoyi Li, out in Cell, leverages a new method for mapping genomic locations of reporters to discover massive chromatin effects on prime editing (PE). We then use 'epigenetic conditioning' to enhance PE. Paper: tinyurl.com/5n8d9mh2

Ever considered measuring genetic variant effects with prime editing but hesitated due to low and variable editing? Last month, 3 papers showed that large-scale screens can work 💪. A 🧵 comparing the papers of the Francisco J. Sánchez-Rivera lab, the Britt Adamson lab, and Greg Findlay

For those who haven't already figured this out from the paper, Jun Yan is a superstar. Can't wait to see what he does next as part of the Marson Lab.

I am really excited to share with you my PhD work in Britt Adamson lab. A huge thanks to all Adamson Lab members, our collaborators, and nature. This project wouldn’t be possible without you.

Amazing work from the Adamson lab out in nature! I'm glad we could try out this promising new prime editing system (PE7) in hematopoietic stem and progenitor cells!

A big week for the lab! See terrific work by Ann Cirincione and Danny Simpson here 👇

Excited to share our work in the Britt Adamson lab using prime editing for multiplexed dropout screens! We built a platform that can reach high-efficiency editing and tested 240,000 epegRNAs for phenotypes. We saw phenotypes we expected and a few we didn't - check here for details!

We are looking for a motivated student to join us as a lab technician: perfect opportunity to gain more research experience for 2 years before applying to MD and/or PhD programs. Follow the link below to apply until Mar. 15: wibr.wd1.myworkdayjobs.com/en-US/WIBR-Car…

Harnessing eukaryotic retroelement proteins for transgene insertion into human safe-harbor loci - Collins Lab go.nature.com/3utPERu

ATR blocks telomerase from converting DNA breaks into telomeres | Science science.org/doi/10.1126/sc…

What started out as a simple 'let's try this in embryos' turned into a full fledged paper! Many many thanks to co-first author Ryan McNulty, our respective PIs Eszter Posfai and Britt Adamson and all authors.

Please join us in-person for the BCMP seminar on Thursday, February 8 at 12:30pm by Britt Adamson, Assistant Professor, Dept of Molecular Biology, Princeton University. Princeton UniversityMolBio Britt Adamson

So happy to see this collab led by Rebecca Kim-Yip 김은정 and Ryan McNulty (@bsadamson lab) published! Congrats to all authors

We tried PE4 out for mouse modeling. Check it out.