What would happen if you got vaccinated against the same antigen over and over again? In The Lancet Infectious Diseases, we now report on a hypervaccinated individual from Magdeburg (HIM) who received 217 vaccinations within 29 months against SARS-CoV-2. 👇 1/19 thelancet.com/journals/lanin…

How did we lose our tail? A simple question.. but it wasn't really asked before! We discovered a plausible scenario for the genetic mechanism that led to tail loss. Amazing that such a big change may have been caused by such a small genetic event. nature.com/articles/s4158… Bo Xia

I am recruiting! Please come join me - looking for an excellent research officer with immunology and viral expertise w a genomics slant 👇 jobs.unimelb.edu.au/caw/en/job/916…

Want to join our awesome team St. Jude Research? We are looking for a Senior Scientist with expertise in Staphylococcus aureus genetics. We offer competitive salary and outstanding benefits. Please retweet. Interested applicant can apply here: talent.stjude.org/careers/jobs/J…

How does antiviral immunity against #influenza evolve across human lifespan? 👶➡️👧➡️👱➡️👵
Our study in Nature Immunology investigates differences in CD8 T cell response across human lifespan-a🧵⬇️ go.unimelb.edu.au/627s
Carolien van de Sandt Katherine Kedzierska Fabio Doherty Institute (1/21)

I'm excited to see our work on immune responses during SARS-CoV-2 breakthrough infection out in Nature Immunology! The results highlight the broad benefits of vaccination and especially the role of memory T cells in the critical early stages of the infection.

nature.com/articles/s4159…

Our lab (schoberlab.de) FAU Erlangen-Nbg is looking for a postdoc at the interface of bioinformatics & immunology. You'll work on T cell immunity to flaviviruses (yellow fever, TBE, Zika, West Nile, etc) within a European Consortium (news soon tba!) karriere.uk-erlangen.de/job/postdoctor…

Have you ever wondered why some people get more sick from the flu than others?

Check out our latest paper from @rmettelman and Aisha Souquette exploring diverse immune correlates of protection against flu nature.com/articles/s4159…

A brief 🧵

Extremely happy to share our latest work on #COVID -19 research identifying a genetic link with asymptomatic COVID infection.

How do people dodge #COVID ?

nature.com/articles/s4158…

🧵below

There was little online material to learn bioinformatics 10 years ago when I started.

I curated ten resources to learn bioinformatics for FREE 🧵👇

Our new paper by Corcoran et al., just out in Immunity, reveals a high variation in human T cell receptor germline genes. The alleles vary greatly in frequency between population groups and some are, surprisingly, inherited from our archaic relatives. authors.elsevier.com/sd/article/S10…

It’s flu season again…How is our immune system protecting us?
It turns out antibodies aren’t the whole picture!
Check out our preprint exploring cell-mediated & innate immune correlates of protection against flu at researchsquare.com/article/rs-237…
by authors:
Robert Mettelman Aisha Souquette
A🧵

Authored by Andrew G. Soerens et al, we show that #Tcells are capable of proliferating in response to iterative stimulation for over 10yrs! And produce enough progeny to occupy a volume 30,000x the Earth's volume! nature nature.com/articles/s4158…

How different are self and nonself? After long years of thinking about this question, excited to share our (surprising?) findings! arxiv.org/abs/2212.12049

I started tinkering with shiny apps for fun and made one for fuzzy matching human TCR CDR3 sequences to a reference database. It's easy to swap in your own ref and customize. Figured I shared it in case anyone found it useful. Happy holidays! github.com/sschattgen/fuz…

Excited to present our Nature Milestones on T cells: go.nature.com/3iwo53k Learn how key discoveries shaped the T cell field, leading to new therapies such as immune checkpoint blockade for cancer. With nature Nature Immunology natureComms #immunology #ScienceHistory

CAIT cells accumulate in Crohns patients and now we know what they see—now to figure out if they are friend or foe! A fun and productive collaboration and a good example of reverse epitope discovery, now for non-canonical ligands.

Are you, like us, wondering WHERE’S that CLONE? On behalf of the ‘Spatial VDJ’ team, here's full-length BCR and TCR mapping in human tissue using spatial transcriptomics (Visium). biorxiv.org/content/10.110… Kim Thrane Qirong Lin Jeffrey Mold Jonas Frisén Joakim Lundeberg thread 1/n

My lab is looking for a junior RA to help out with some really exciting projects on T cell development, recognition, activation and senescence....all of it!! Please apply, we're a fun bunch...you won't regret it.
uniroles.com.au/display-job/32…

Go T cells! How can a Vaccinia virus (VACV) vaccine help us against the Monkeypox (MPXV) outbreak? In our new study we show how our beloved T cells are there to help you and how the vaccine can give them enough information to recognize the new virus.