FOXO1 drives memory programming, stemness, and metabolic programming in CAR T cells nature Mackall Lab Evan Weber Junyun Lai A/Prof Paul Beavis DarcyLab Peter Mac Cancer Centre
nature.com/articles/s4158…
nature.com/articles/s4158…

#MysterySolved ! Krönke &co show nature that glucocorticoids are anti-inflammatory not in a transcriptional manner (🤯), but by boosting the Krebs cycle in macrophages, driving excessive #itaconate that interferes with pro-inflammatory cytokine induction! Doi.org/10.1038/s41586…

Memory genes are enriched in CAR T cells that persist and control tumors in patients. But which transcription factors drive beneficial memory programs?

We answer this in our lab’s first paper in nature led by Alex Doan Kat Mueller, PhD Andy Chen. 1/

nature.com/articles/s4158…

Flu virus infections can cause life-threatening lung damage in some patients. Our researchers helped create a new drug that gives promise for treating patients with advanced infections and potentially saving lives.

Read more from Paul G Thomas in nature. bit.ly/3JbNfye

I am very excited to see this in print!

New work from our lab defines an interferon-induced memory B cell subset during chronic viral infection.

An awesome effort by Lucy Cooper Lucy Cooper & supported by our generous lab members & collaborators

Monash Biomedicine Discovery Institute Immunity

The difference in 10x Genomics' Cell Ranger's default between version 6 and 7 is discussed in this thread, but it's such a big deal that it's worth its own thread.

tl;dr: in v7 Cell Ranger changed how it produces the gene count matrix leading to a huge difference in results. 1/

Online now: DNAJB1-PRKACA fusion neoantigens elicit rare endogenous T cell responses that potentiate cell therapy for fibrolamellar carcinoma dlvr.it/T4dtV7

Congratulations to multiple cancer center members including Dr. Evan Glazer for this groundbreaking effort in the rare disease fibrolamellar carcinoma and our collaboration with St. Jude.
The University of Tennessee Health Science Center UTHSC Research UTHSC Center for Cancer Research St. Jude

cell.com/cell-reports-m…

H5N1 has now been reported in cows in several states in the US. I wouldn't be surprised if there are infections in cows in Europe too. Maybe people should start looking.

Richard Webby, PhD, Virologist at St. Jude, is researching the spread of the H5N1 bird flu virus as it aggressively spreads in non-human mammals. Find out what is raising the alarm in Reuters Science News. ow.ly/tn5y50QUH7i

A little insight…

DNAJB1-PRKACA fusion neoantigens elicit rare endogenous T cell responses that potentiate cell therapy for fibrolamellar carcinoma
cell.com/cell-reports-m…