Mendelian Randomisation (MR) is going to hell in a handcart, with an exponential weekly increase of papers with Mendelian Randomisation in the title, most of them nonsense. 25th April 4.30pm online or in person UCL I'll talk about what should be done forms.office.com/pages/response…

Patients, the public, as well as health care professionals carry very strong but misinformed opinions about bariatric surgery.

It always amazes me what we can get from an organ donor pancreas with type 1 diabetes. Tremendously valuable for understanding the disease. Massive respect to families that support research. (Reddish staining indicates cells with insulin).

As we gear up to release our new human islet data resource (soon I hope!), a couple of papers we’ve been fortunate to work on with colleagues in Jeff Xia’s group at McGill…both incorporating some human islet data. 1/2

academic.oup.com/nar/advance-ar…

The research into curing type 1 DM may also prove quite promising in type 2 DM in generating healthy beta-cells over time even after weight loss. I also look forward to seeing any 10 yr data on maintenance of glucose control with new generation incretins like tirzepatide.

A mark of emotional maturity is hearing disagreement without taking offense.

Thoughtful dissent doesn't always mean you're wrong. It often means the issue is complex and your knowledge is incomplete.

Good-faith debate isn't an attack. It's an opportunity to sharpen your ideas.

Shhh!!! 🤫 if a lot of people start this early in life I won’t have any work to do.

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Our evidence-based healthy lifestyle program is now open to the public! We launch this Monday, April 15.

Learn more and join here! mhealth.inchip.uconn.edu/health-is-soci…

Catholic Dietitian I agree 'shadow of their disease' is a silly term... It is in reference to Roy Taylor's description of DiRECT trial. Bariatric Surgery is the best treatment we have for diabetes & those that don't stay in 'remission' are going to do fantastic w/ less drugs & better outcomes.

Ozzie the cat and Jrako the bearded dragon are also friends. Ozzie spends a lot time with him so we pulled up a chair for him where he hangs out and naps.

Now that we have about two dozen LLMs in the market, here are the dimensions that matter when it comes to using them.

Reasoning - Claude 3 Opus beats everything out

Code - GPT-4 is still king here

Cost - Claude Haiku is your best bet

Latency - Claude or a local open-source…

It’s clear from this that no intervention to date demonstrates individuals with T2D can “confidentially escape the shadow of their disease”. We need to move from false hope of “diabetes remission” and “diabetes reversal” to best management and support in a timely fashion.

Google Scholar just introduced a PDF Reader and Adobe put an AI Assistant in Acrobat PDF Reader:

Anna Borek 🐌 Michael Mindrum ☸️ Shaun Ward What an interesting discussion. Modern science has taught us that obesity arises when a complex system controlling appetite and energy storage fails. We did not know of this system 30 years ago. Willpower is sometimes useful when treating obesity. As goes for many other diseases.

I used to think liberalism was akin to being “open minded.” This seems to be increasingly untrue in institutions & media. My hope is that people begin to have a distaste for any ideology, including DEI, that collapses in upon itself by the weight of its own agreements.

Equating “tastiness” to hedonic response is an important misunderstanding. Need to separate the conscious experience of “liking” from the powerful non-conscious motivational-hedonic drive of “wanting”. Perhaps that understanding would lead the CIM folks somewhere useful?

Duration, frequency, and intensity are all essential domains or levers in driving athletic performance/ fitness.
But... What are you trying to optimize for??
Also... are you just starting out??
For me, optimizing for a longer, healthier life involves primarily frequency and…