Markus Eckstein
@Markuseckstein3
#Pathologist #Physician Scientist @UniFAU University Hospital Erlangen, Germany #pathology #biomarker_research - My opinions are my own
ID:884523385488855042
https://www.pathologie.uk-erlangen.de 10-07-2017 21:23:03
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Really interesting article by Niklas Klümper in EJC 🤓🤓
Post-hoc analyses from the IMvigor211 and IMmotion151 💉💉
A simple and cheap predictor of IO efficacy >Blood sodium levels 🧂🧂
Could be very practical and beneficial for the patients 🤞🤞
A great discussion on the…
We are happy to share our new study published today Journal of Clinical Oncology (👉 ascopubs.org/doi/10.1200/JC…) on the role of NECTIN4 amplifications to predict responses to Enfortumab Vedotin treatment in metastatic urothelial cancer.
With a huge contribution of our multinational team we uncovered…
🚨New Paper Alert! 🚨Targeting NECTIN4. Predicting Response to Enfortumab Vedotin in Metastatic Urothelial Cancer
Journal of Clinical Oncology Niklas Klümper Markus Eckstein Michael Hölzel Viktor Grünwald Joshua Meeks Christoph Kuppe Else Kröner-Fresenius-Stiftung
Summary by Amalya Sargsyan
oncodaily.com/58904.html
Very important study from a team led by Markus Eckstein Niklas Klümper highlighting NECTIN4 amplification as a potential predictive biomarker for treatment with EV in #BladderCancer patients Petros Grivas Amanda Nizam, MD Uromigos IBCG Bladder Cancer Advocacy Network
Interesting work from Niklas Klümper et al —Na levels may module ICB response. Still so much unknown in this area. Congrats for the elegant work Niklas!
Fantastic work on molecular subtypes Cancer Cell paper & awesome commentary Chadi Hage Chehade Neeraj Agarwal, MD, FASCO Huntsman Cancer Institute UroToday.com Kidney Cancer KidneyCAN Toni Choueiri, MD Chris Labaki Bradley McGregor Brian Rini, MD Laurence Albiges Talal El Zarif, MD Uromigos Sumanta K. Pal, MD, FASCO Robert Motzer MD Tom Powles OncoAlert
Happy to share our editorial recently published in Cancer Cell ! Grateful for terrific mentorship from Neeraj Agarwal, MD, FASCO and team Umang Swami Benjamin L Maughan Georges Gebrael GU Cancer Research Program @HuntsmanCancer 👉tinyurl.com/48px5rw8👇👇
Niklas Klümper Journal of Clinical Oncology Great work and looking forward to more data in the future- the big question is whether patients without amplification or overexpression do better with other treatments than with EV- this requires biomarker directed prospective trials to answer this question.
Great work by Niklas Klümper et al. finding that 24% of mUC have Nectin4 ampl, which predicts ⬆️ORR (96% vs 32%) & ⬆️OS with the ADC #EV . Excited to see EV data for MBC presented at ASCO by Antonio Giordano, MD PhD & to study this biomarker in breast cancer. Congrats! ascopubs.org/doi/full/10.12…
Happy to share a collaborative work where I was involved as „immunopathologist“ Nature Medicine ! Beside my oncology hobby we provide services for tissue monitoring therapy responses to autoimmune diseases.
Led by Ricardo Grieshaber-Bouyer and Georg Schett our study shows
👉 that…
Congratulations 👏👏👏
With the rise of antibody-drug conjugates, precise biomarker identification is key to revolutionizing care. #CancerResearch #PersonalizedMedicine #ClinicalOncology 🧬💊🔬
🚨 Does TP53 status overshadows the prognostic significance of HPV in penile cancer patients?
❗️Read all about it in the first single-cell RNA sequencing atlas of penile cancer: authors.elsevier.com/a/1i%7Elg14kpl…
European Urology
Let’s go on a biological journey through this paper:🧵(1/9)