New bioRxiv manuscript finds mitochondrial pyruvate carrier inhibitor MSDC-0160 can attenuate neurodegeneration in a rodent (6OHDA) model of #Parkinsons;⬇️ mTOR activity & neuroinflammation, plus⬆️ketogenesis, beta oxidation & glutamate oxidation biorxiv.org/content/10.110…

#ClinicalMedicine: A metabolic biomarker predicts Parkinson’s disease at the early stages in patients and animal models: buff.ly/3syHv92 GIN Neuro Grenoble Inserm #Metabolism #Neuroscience

Des chercheurs grenoblois pensent pouvoir détecter précocement la maladie de Parkinson avec une prise de sang - placegrenet.fr/2022/02/17/des…

Hier matin, @AMorelch sur France Inter a consacré un sujet aux travaux de Mallet David, F. Fauvelle et S. Boulet sur la découverte d'un biomarqueur métabolique capable de détecter de manière précoce la maladie de #Parkinson. Replay disponible à 9min35: franceinter.fr/emissions/le-j…

🎥 French TV appearance on the occasion of the #WorldParkinsonsDay France 3 Alpes gave us the opportunity to talk to the general public about our research on an early blood biomarker for the diagnosis of Parkinson's disease. youtu.be/02ucLNf61MQ #ParkinsonsDisease

Back in business 🧬🧬 #metabolomic

I am thrilled to present a poster at #fens2022 on Brain mitochondrial reprogramming as a biomarker and therapeutic target Date & Time: 12th July 14.00-17.30 Poster session 6, board number S06-342

Another fantastic work from Meaghan Creed lab by Yvan Vachez

Thrilled to share this new paper on the modulation of energetic metabolism induced by MPC inhibition as a neuroprotective strategy. Springer Nature #mitochondria #mpc #parkinson

Excessive daytime sleepiness in a nonhuman primate model of #Parkinsons was improved by low-frequency stimulation of the pedunculopontine nucleus nature.com/articles/s4153…

A review from the lab from two great postdocs Dogukan Ulgen and Silvie Ruigrok is out and available through the link below. Powering the social brain: Mitochondria in social behaviour sciencedirect.com/science/articl… EPFL Brain Mind Institute NeuroLéman StressNetwork.ch

Just out from the lab! New read! We show that mitochondrial mitofusin 2 in nucleus accumbens D2, but not D1, medium spiny neurons regulates social dominance & mito & neuronal phenotypes! Congrats to Sriparna Ghosal S_Astori &all the team! cell.com/cell-reports/f… EPFL Brain Mind Institute

Did you ever wonder "Why we don't all develop posttraumatic stress disorder"? See key insights in our last paper led by Silvia M. & S Astori & collaboration with BRAIN authors.elsevier.com/sd/article/S00… Biological Psychiatry & press release EPFL Life Sciences EPFL actu.epfl.ch/news/why-we-do… #epfl

The paper is finally out! Congratulations to Anna Kaźmierowska, Mateusz Kostecki (@matkstecki), and Michał Szczepanik. Thank you, Artur Marchewka, Marek Wypych, and Jarosław Michałowski for the excellent collaboration (Lobi_Nencki): pnas.org/doi/10.1073/pn…

The first cellular map of a mammalian brain is here. 🧠✨ Over 6 years and 32 million cells in the making, the complete adult mouse brain cell-type atlas reveals astonishing diversity and regional specificity. Dive deeper: alleninstitute.org/scientists-unv… @nature #studyBRAIN #BICCN

New lab paper! We reveal a novel mitochondria–cilia interaction in neurons & show #mitochondrial control of #ciliary molecular pathways & structure Kudos to D Ulgen & Alessandro Chioino 🙏 Olivia Zan. Albert Quintana & E Sanz EPFL Brain Mind Institute NeuroLéman Read doi.org/10.1113/JP2879…