Just brilliant! nytimes.com/interactive/20…

Trying to reproduce other groups' protocols #Easy

Researchers Clarify Why Measles Doesn’t Evolve to Escape Immunity discoverysedge.mayo.edu/2021/03/30/res… Discovery's Edge Cell Reports Medicine

Mayo Clinic scientists conclude in new publication that there is a near-zero probability for the natural emergence of a new measles virus capable of evading vaccine-induced immunity. Read more: mayocl.in/3sHD3UD

Live-attenuated measles virus (MeV) remains antigenically monotypic. Escape from serum neutralization requires elimination of at least 5 co-dominant antigenic sites in the Hemagglutinin (H)-glycoprotein. Emergence of new serotypes is highly unlikely. Mayo Clinic Miguel Ángel Muñoz-Alía

We've written a perspective on a new study by Miguel Ángel Muñoz-Alía that helps explain why some viruses (measles) don't evolve to escape immunity but others (influenza) do. Provides some clues relevant to future for #SARSCoV2 as well: cell.com/cell-reports-m… Here is a recap: (1/n)

Now Miguel Ángel Muñoz-Alía has completed the picture with a new study in Cell Reports Medicine showing that measles polyclonal antibodies have very broad activity, such that no single (or even double or triple) mutant has much reduction in neutralization (cell.com/cell-reports-m…). (11/n)

Shanmuga_Sozhamannan@AuSpread Hello, please find the unroll here: We've written a perspective on a new study by Miguel Ángel Muñoz-Alía that… threadreaderapp.com/thread/1385664… Share this if you think it's interesting. 🤖

Absolutely delighted about #TWiV featuring our work on the constraints on measles antigenic evolution. Shout out to Bloom Lab, Cell Reports Medicine and Isabel Goldman for also giving visibility to our work.

Not only do we have vaccines that can prevent covid infections from all variants, but we also have monoclonal antibodies that can protect vs/treat all of the variants that have emerged to date cell.com/cell/fulltext/… New Cell

"The fact it has happened twice in 18 months, two lineages (Alpha and then Delta) each 50% more transmissible is a phenomenal amount of change"—Aris Katzourakis bbc.com/news/health-57… by James Gallagher BBC Health News

Just published Cell report on the Delta variant's immune evasion property: —Less than Beta (good!) —Vaccines should hold up (as effectiveness data supports) —Prior covid with beta or gamma variants susceptible to reinfection by delta cell.com/cell/fulltext/…

*New paper alert* I'm happy to share that our manuscript "Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2" is now published in Science Magazine. you can find it here: science.sciencemag.org/content/early/…. I did a long thread for the preprint a year ago :)

1/ Here is a comprehensive review of the data on whether we need COVID BOOSTER SHOTS. THE MOST IMPORTANT TAKEAWAY: IF YOU HAVEN'T YET GOTTEN A COVID VACCINE, NOW'S THE TIME! I'll put a Threadreader unroll at the end for those of you who find that more convenient to read/share.

If you are interested in our efforts on a new measles vaccine for early immunization of infants, stay tuned tomorrow, July 22 at #ASV2021. W36-7 at 3.30pm CT

10 mind-blowing AI websites you probably didn't know existed:

Surface-modified measles vaccines encoding oligomeric, fusion-stabilized SARS-CoV-2 spike glycoproteins bypass measles ... biorxiv.org/cgi/content/sh… #biorxiv_micrbio

Exciting news! Our research on "Surface-modified measles vaccines boosting neutralizing antibodies against Omicron and historical variants" is an Editor's Pick! Read it here: mBio journals.asm.org/doi/10.1128/mb… #Vaccines #COVID19 #measles