mTORC1 regulates cell survival under glucose starvation through 4EBP1/2-mediated translational reprogramming of fatty acid metabolism nature.com/articles/s4146… Congrats Barak Rotblat and Leprivier Lab "Stress responses and cancer"

Answer any biology question with knowledge graphs + novel hypothesis + insights. Access 122k full papers biologpt.com

The work of Xiaoxu Li and collaborators defines a simple continuous and composite trait, termed the metabolic health score, that is more accurate in defining metabolic homeostasis and predicting future disease incidence sciencedirect.com/science/articl…

There is still time for abstract submission! Please, share! 😊

Principal component-based clinical aging clocks identify signatures of healthy aging and targets for clinical intervention 👍👍Nature Aging @ Sheng Fong Kamil Pabis Brian Kennedy et al. nature.com/articles/s4358…

Tips and tricks for building a good paper: what editors want (1/5)

Cyclic fasting-mimicking diet in cancer treatment: Preclinical and clinical evidence dlvr.it/TBqHP3

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I will be teaching and telling people why they should support basic research in simple model organisms till I die - though they don’t get the same recognition in terms of NIH finding - glad to see them recognized by the Nobel committee. Congratulations Gary Ruvkun

📢 I am so incredibly happy and proud about this one! 🔟+ years in the making, 2,5 years since first submission, 1⃣ year since we posted it bioRxiv, it finally found it’s home Nature Cell Biology! Open access 👇 nature.com/articles/s4155… Detailed 🧵down below ⏬

The paper highlights a paradox known for some time. Greater CR leads to more life extension. Greater CR also leads to greater fat loss. BUT among those at a given level of restriction it is the ones who lose the least weight that live longest!! go figure.....

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We have a #PhDposition to investigate host - #microbiome interactions using #Drosophila and model gut #bacteria. Details in the picture attached. Be part of our new group @COSHeidelberg in beautiful Heidelberg! Please RT

Nobel Forum-Nordic Ageing Society meeting

New! Online now: Adipocyte-derived glutathione promotes obesity-related breast cancer by regulating the SCARB2-ARF1-mTORC1 complex dlvr.it/TFcPSh

All rejected papers share one common flaw: a weak discussion section. I know because I used to write them too. If you're stuck on the discussion section, wondering how to tie it all together, this is for you:

Mitochondrial fatty acid oxidation drives senescence | Science Advances science.org/doi/10.1126/sc…

💥New paper from our group Molecular Cell! 🎃 One-woman show by the amazing Aish Acharya Aishwarya Acharya, revealing how active #mTORC1 sets itself free from #lysosomes! Link (Open Access 🔓) 👇 sciencedirect.com/science/articl… Detailed 🧵 below ⏬

🎉 The results are in! Here is the preprint reporting the result of Phase I of the Biomarkers of Aging Challenge, an open competition for the best biomarker of aging models with a 200,000 USD prize! Biomarkers of Aging Consortium 🏆Big congrats and thanks to our phase I winners (Julian,

MIT Course announcement: Machine Learning for Computational Biology #MLCB25 Fall'24 Lecture Videos: tinyurl.com/MLCBlectures Fall'24 Lecture Notes: tinyurl.com/MLCB24notes (a) Genomes: Statistical genomics, gene regulation, genome language models, chromatin structure, 3D genome