What is the relationship between mRNA translation and aging? More translation leads to accumulation of misfolded proteins, which is linked to aging. SIRT6 is an inhibitor of this by keeping mRNA translation in check. See latest study of Debbie Toiber lab.

FOR THE LOVE OF PURINES: We are truly excited to share our latest work on mapping the routes of purine nucleotide synthesis in vivo-De novo and Salvage Purine Synthesis Pathways Across Tissues and Tumors Cell Press. A huge team and collaborative effort! Congratulations, ALL!

biorxiv.org/content/10.110… Thrilled to present our manuscript identifying an alternative selenocysteine (Sec) metabolism pathway! 🚀 PRDX6, not just SCLY, can mediate Sec metabolization, playing a key role in ferroptosis response. Congrats to all authors!#Metabolism #Ferroptosis

Also point out a recent preprint from the The Conrad Lab biorxiv.org/content/10.110… coming to similar conclusions. Great minds think a like 🤪 or maybe the opposite is true😅

Super star Toshitaka Nakamura strikes again - check out our most recent update on #ferroptosis in #cancer! out in Nature Cell Biology - enjoy! nature.com/articles/s4155…

Amazing discovery on the evolution of human pigmentation by retrotransposons! Turns out TEs not only helped us get rid of our tails (see 1st comment) but also adapt to different levels of sunlight exposure . nature.com/articles/s4158…😎

How to deliver proteins into the brain? Just ask a parasite. See the latest work from Oded Rechavi team and collaborators. rdcu.be/dPqrW

It’s very rare for a celebrity to speak at length about a complicated situation in another country and get it right. Javier Bardem does it here, and I hope you have a few minutes to listen to this. The Spanish is beautiful and the translation is good.

Coffee break at the YPI Crete conference

A long time in the making "#KRAS G12 mutant alleles differentially control glutamine #metabolism via #FOXO1", still warm from the bakery bioRxiv Cancer Bio. Massive thanks to SUZAN! and all other amazing collaborators/friends... doi.org/10.1101/2024.1… #colorectalcancer

Amazing Crete Conference 2024 with so many friends and awesome discussions ⁦Debbie Toiber⁩ ⁦Oded Rechavi⁩ ⁦Barak Rotblat⁩ ⁦@GrunewaldLab⁩ ⁦Leprivier Lab "Stress responses and cancer"⁩

Nutrient control of growth and metabolism through mTORC1 regulation of mRNA splicing dlvr.it/TGdrLj

Happy to announce our collaboration with Kaechlab (Sue Kaech) on metabolic features of exhausted T cells is now out in Science Magazine. TL;DR they can't use acetate to fuel their function. Great work by Shixin Ma and Mike Dahabieh. science.org/doi/10.1126/sc…

Exhausted T cells reprogram histone acetylation by switching acetate to citrate related metabolism. See the latest story of Russell Jones. Nutrient-driven histone code determines exhausted CD8+ T cell fates | Science science.org/doi/10.1126/sc…

I am excited to preprint my postdoc work in the James Olzmann! We have discovered the first lipid droplet quality control pathway with broad implications for lipid physiology and diseases associated with LD accumulation and oxidative stress! #lipidtime shorturl.at/2HqFd

I know, I know... HHS freezes are occupying our attention. Please free up a little bandwidth for this: nature.com/articles/d4158… NASA FOUND AN ASTEROID WITH ALL 5 NUCLEOBASES & 14 L-AMINO ACIDS!! WAIT, THERE'S MORE: THE ASTEROID CONTAINS NEARLY EQUAL AMOUNTS OF D-AMINO ACIDS!

Caspase-like immunity in bacteria. More evidence supporting the hypothesis that cellular suicide mechanisms (apoptosis, pyroptosis) evolved in the context of self-defense science.org/doi/10.1126/sc…

Metabolism (and horse) nerds: You have to check out this paper! Keap1 mutations in equine species permit increased Nrf2 activity and help explain why horses have such big, strong, oxygen consuming muscles 💪🏼🐴 The nature of the mutation is as provocative as the physiological

Being a PI is hard, we have to deal with one rejection after another, hours of work amounting to nothing because someone thinks our ideas aren’t cool enough. But then, suddenly, you get a yes! And life shines again. Thanks, DFG public | @[email protected], for your support!

New insights on the biology of Ewing sarcoma. Of the importance of tryptophan metabolism. See the new study from Grünewald's lab and colleagues. biorxiv.org/content/10.110…