I am always shocked at the number of bizarre things people do to "optimize" their health and longevity and yet they don't exercise regularly, sleep 7-9 hours, eat fruits and veggies, build intimate bonds and community, or ever relax. They obsess over the 0.1% but not the 99.9%.

Whatever you think of Bryan Johnson you can't deny he is brave... He just completed an experimental gene therapy on himself, editing his DNA, which is potentially dangerous and not FDA approved. And he will probably open-source the results. Hero. youtu.be/bax8to_s07Q?si…

>90% of UK deaths are caused by ageing, so where do the parties stand on longevity science? I looked through the #GeneralElection2024 manifestos! The Labour Party: no mention Conservatives: nothing Reform UK: rien Liberal Democrats: - The Green Party: nope The SNP: nada Plaid Cymru 🏴󠁧󠁢󠁷󠁬󠁳󠁿: zero

This paper will make waves in the aging research community and the results will need to be replicated (I would not fully believe it until I see ITP data) but looks very promising. IL-11 and downstream targets are very promising. Congrats to the team and kudos to Singapore!

This new paper provides a potential explanation for why psilocybin has such a profound impact on alleviating depression... It indicates a long lasting reduction in self-focused thinking and rumination!

Pet Longevity genuinely seems like it might be the best risk/return opportunity for allocating capital in the longevity space

UK just might become a leader in longevity — watch this great speech in the House of Lords by Evgeny Lebedev:

Why do people avoid directly expressing the desire: "I don't want to die"? It's not just about disappointment: it will happen anyway, so why upset yourself? It's not just about becoming an outcast: people will think you're strange. The fear of death doesn't raise social status.

In the sciences, the authority of thousands of opinions is not worth as much as one tiny spark of reason in an individual man. — Galileo Galilei

The crossover between crypto and longevity folk seems confusing at first... Both require you to deeply question concepts that most people hold as unquestionable: money and death. Worth a listen to Brian Armstrong with Niklas Anzinger 📍 Infinita podcasts.apple.com/gb/podcast/ep-…

Exciting news - Vincere has teamed up with Beiersdorf, the company behind leading skin care brands like NIVEA and Eucerin, to develop mitophagy-enhancing molecules for anti-aging skin care! You can learn more and chat with the team at: linkedin.com/posts/vincere-…

How can you use Reinforcement Learning to make better proteins and what does a “Move 37” moment in protein design look like? We’re taking a look at ProtRL: a framework for aligning protein language models to your desired distributions using reinforcement learning. Filippo Stocco

Scott Alexander has written a great article on the burgeoning field of embryo selection, featuring our recently launched company Herasight. Scott has used the technology himself and gives an overview of the field - this is an essential read for anyone curious to learn more.

1/n Fun journey continues: Our new Cell Stem Cell paper out on how the Inherent & Dormant Plasticity of mouse naive PSCs can be "Exaggerated" to Directly form ~E8.5 Transgene-Free (TF) Mouse SEMs & WITHOUT inducing 8-16-Morula-like "Embryo Founder Cells". cell.com/cell-stem-cell…

Cell therapies have enormous potential in longevity and regenerative medicine more broadly. But why are they still so expensive and hard to scale? Read more from our CSO Partner, Manish Chamoli PhD longgamevc.substack.com/p/scaling-cell…