Dysregulation of self-renewal contributes to alterations in alveolar macrophages. Penke et al identify PGE2 as a suppressor of AM proliferation whose divergent bioavailability in aged & cigarette smoke-exposed mice could explain opposite effects on AM #'s. bit.ly/3bbLrDA

New Review online! Tyrrell and Goldstein discuss vascular intrinsic and extrinsic mechanisms by which #aging promotes #atherosclerosis rdcu.be/b64Qy Daniel R. Goldstein @dantyrr The Goldstein Lab@UM Michigan Medicine U-M Health Frankel CVC

Senescence associates with fibrotic lung diseases. Emerging therapies to reduce senescence may treat chronic lung diseases, but the impact of senescence during acute respiratory viral infections is unclear and requires future investigation. erj.ersjournals.com/content/early/…

Great job Billy!

Join us tomorrow for our symposium "Mechanisms of declining protective immunity despite heightened chronic inflammation during aging" Chaired by @DrEmilyGoldberg! Speakers Dawn Bowdish, Mladen Jergovic, Elsa Bou Ghanem, and Dan Winer! Links at lamminglab.org/agingscitalks.…

Congrats to Dan Tyrrell @dantyrr well deserved after working so hard to revise paper during the shutdown from #COVID19!

Jan'21 Issue of JHLT of The ISHLT online now! Great science: #lungtransplantation #MCS #pediatric heart transplantation. Look for tweets from Yas Moayedi + Aman Sidhu Thanks: @MRMehraMD 10 yrs of leadership + ongoing advice jhltonline.org/current

Our JHLT Jan podcast will feature this study: Donor ventilation parameters and lung transplantation. Podcast contributed by Dr. Erika Lease University of Washington Stay tuned! Yas Moayedi Aman Sidhu The ISHLT U-M Health Frankel CVC jhltonline.org/article/S1053-…

Our Jan'21 podcast JHLT The ISHLT will feature this study: thrombosis events + LVADS. Contributed by Marty Tam Khue Ton Stay tuned! Yas Moayedi Aman Sidhu U-M Health Frankel CVC jhltonline.org/article/S1053-…

Happy Holidays + Merry Xmas! #Senolytics - being evaluated in multiple conditions. Would they work in acute respiratory viral infections? Not clear: check our perspective at ERS publications U-M Health Frankel CVC U-M Department of Internal Medicine UMich Imm Grad Prog erj.ersjournals.com/content/56/6/2…

Looking for post docs esp recent grads The Goldstein Lab@UM sites.google.com/umich.edu/gold… Dept of Microbiology & Immunology @ the Univ of MI @UmichCVC @UmichImmunology #mitochondrial function in age assoc conditions: #respiratory viral infections + #vascular inflammation careers.umich.edu/job_detail/193…

V honored to be elected to the AAP aap-online.org Thanks to all who supported me. Thanks also to U-M Health Frankel CVC Michigan Medicine U-M Department of Internal Medicine for allowing my research to flourish. Thanks to The Goldstein Lab@UM for working so hard! Go Blue! University of Michigan

Great job! Judy Chen Judy Chen and Billy Kelley of The Goldstein Lab@UM UMich Imm Grad Prog Dept of Microbiology & Immunology @ the Univ of MI - their #COVID19 and #aging review is top 10 read March'21 at The Journal Immunology The American Association of Immunologists (AAI) mailchi.mp/aai/the-journa…

Want to know a mechanism by which #aging impairs #influenza infection? Check out👇 by super grad student Judy Chen UMich Imm Grad Prog U-M Health Frankel CVC Dept of Microbiology & Immunology @ the Univ of MI Michigan Medicine biorxiv.org/content/10.110…

Check out the preprint from Grad Student Judy Chen working in The Goldstein Lab@UM showing PGE2 regulates flu susceptibility in aged mice biorxiv.org/content/10.110…

@dantyrr UAB Heersink School of Medicine UAB Pathology So proud of you! Fantastic work at The Goldstein Lab@UM Michigan Medicine U-M Health Frankel CVC wishing you all the best!

Forget to tag The Goldstein Lab@UM! Nice work!

Gabby Fredman The Goldstein Lab@UM Thanks so much for highlighting our work at UMich Imm Grad Prog University of Michigan

Check out our paper JCI insight on nanotherapeutics to improve outcomes during #influenza with aging Michigan Medicine Dept of Microbiology & Immunology @ the Univ of MI U-M Health Frankel CVC U-M Department of Internal Medicine The Goldstein Lab@UM Michigan Cardiology Michigan Research UMich Imm Grad Prog insight.jci.org/articles/view/…

How does #aging increase mortality to #influenza? Our study by brilliant grad student Judy Chen at The Goldstein Lab@UM Dept of Microbiology & Immunology @ the Univ of MI U-M Department of Internal Medicine U-M Health Frankel CVC Michigan Research Michigan Cardiology provides an answer: doi.org/10.1038/s41467… PDF nature.com/articles/s4146….