How does multisite #phosphorylation of an #E2 enzyme dictate its pairing with a multisubunit #E3 #ubiquitin ligase to regulate metabolism? Check out our story available now in Molecular Cell! ➡️ cell.com/molecular-cell… D.Sherpa Schulman lab Max Planck Institute of Biochemistry (MPIB)

Excited to share our structural snapshots of MZ1-targeted Brd4BD2 ubiquitination in bioRxiv! Alessio Ciulli Centre for Targeted Protein Degradation We use cryo-EM to capture states of the dynamic Brd4BD2-MZ1-(NEDD8)-CRL2VHL-UBE2R-Ub complex 🔗doi.org/10.1101/2024.0…

See how CRLs forge ubiquitin chains on substrates - and degrader-recruited neo-substrate - at high-res! Millisecond polyubiquitylation! #cryoEM #TPD NatureStructMolBiol Max Planck Institute of Biochemistry (MPIB) UNLV College of Sciences 👉shorturl.at/eFS68 Related exciting work from Alessio Ciulli shorturl.at/hNSU5

After a long journey, I am thrilled to announce that our collaborative paper is finally out in Nature Chemistry ! Can cryo-EM capture the metastable ADP.Pi state, where ATP is hydrolyzed but ADP and the cleaved Pi ion still remain in the nucleotide pocket?nature.com/articles/s4155…

Roses are red Violets are blue If you love Cryogenic Electron Microscopy This job ad is for you: jobs.brassring.com/1033/ASP/TG/ci…

I am happy, proud, and a bit psyched that our ubiquitin-focused issue is finally out! Are you ready, 'cause this about to get heavy? For a synopsis of this month's great ubi content NatureStructMolBiol, have a garner at our editorial nature.com/articles/s4159… and the🧵

Excited to present our latest research nature where we unveil the mystery of UFMylation, a crucial process for protein homeostasis at the ER nature.com/articles/s4158…

Congratulations to Kheewoong Baek, a postdoc in Fischer Lab, and other recipients of Damon Runyon Cancer Research Foundation Cancer Research Foundation award to top young scientists. damonrunyon.org/news/entries/7…

We are delighted to welcome a new class of Damon Runyon Fellows! Learn more about these talented researchers and the questions they'll work to answer as Damon Runyon scientists: damonrunyon.org/news/entries/7…

Kheewoong Baek 🎉🥳👏

Congratulations Kheewoong Baek 👏🎉

Congratulations to Kheewoong Baek from Fischer Lab on being named a Damon Runyon Cancer Research Foundation Fellow!

Excited to share E3-substrate tagging by ubiquitin biotinylation (E-STUB) Nature Chemical Biology! E-STUB enables CUL-RING ligase substrate identification and may transform the way we study glues and PROTACs by directly studying substrate ubiquitylation. 1/ rdcu.be/dBZKx

Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF disq.us/t/4nmwglh 🤝 Proud to collaborate with Sandi Radko-Juettner on this groundbreaking research. Together, we're advancing cancer therapeutics and structural biology. Stay tuned for more updates!

Nice work from Gray and Fischer Lab labs on combinatorial libraries for CRBN molecular glue discovery that yielded a WEE1 degrader. biorxiv.org/content/10.110…

I am happy to share that I will be starting an assistant professor position at the Van Andel Research Institute Van Andel Institute (VAI) in the Department of Neurodegenerative Science. My lab is opening in July, and I am currently hiring: vai.wd1.myworkdayjobs.com/en-US/VAICaree… and vai.wd1.myworkdayjobs.com/en-US/VAICaree…

Extremely grateful and honored to receive the Otto Hahn Medal from the Max Planck Society Max Planck Society . Thank you Brenda Schulman Max Planck Institute of Biochemistry (MPIB) , Arno Alpi , Jakub Chrustowicz , past and present GID team members and the Schulman Lab family for making this possible.

The lab surprised me with a celebration today for my promotion to Associate Professor with tenure here at OHSU-MMI! Huge thanks to current and past lab members for setting us on this path, and to all of my mentors within the scientific community!

It official! The Hoyer lab has opened it's doors at the Van Andel Institute (VAI) in VAI Department of Neurodegenerative Science. For more information check out our website: hoyerlab.vai.org This is such an exciting adventure. I am thankful to my family, friends, and mentors who have helped me get here!