How can models "overfit" and fail to predict in #immunology? Our collaborators Steven Kleinstein 🖥 Leying (Lexi) Guan + Jeremy Gygi explain in new paper. ncbi.nlm.nih.gov/pmc/articles/P…

I am excited to announce our paper predicting #immune responses after B. pertussis (#whoopingcough) booster vaccination based on the pre-vaccination immune state is coming out in the March 25th issue on Cell Reports Methods cell.com/cell-reports-m… #SystemsBiology #Bioinformatics (1/8)

So happy to have had the chance to present our work on SPEAR with Leying (Lexi) Guan and Steven Kleinstein 🖥 at the HIPC annual meeting! Grateful for all the valuable insight and interest.

SPEAR: A supervised bayesian factor model for the identification of multi-omics signatures academic.oup.com/bioinformatics…

Excited to share my latest research on #COVID19 and #aging, together with Alexandra Tsitsiklis and Cole Maguire, that just came out on Science Translational Medicine! x.com/czbiohub/statu…

Integrated longitudinal multiomics study identifies immune programs associated with acute COVID-19 severity and mortality Journal of Clinical Investigation Leying (Lexi) Guan jci.org/articles/view/…

I am excited to share that our #IMPACC paper - Integrated longitudinal multi-omics study identifies immune programs associated with acute COVID-19 severity and mortality - was recently published in Journal of Clinical Investigation. jci.org/articles/view/… #SystemsBiology #Bioinformatics [1/5]

Our recent #IMPACC #COVID19 #multiomics study published in Journal of Clinical Investigation is featured in @yalemed! Read about it: "COVID-19: New ‘Omics’ Models Show Why Some People Are at Greater Risk of Severe Disease, Death" m.yale.edu/ckst Leying (Lexi) Guan Cole Maguire Ravi K. Patel

Congratulations to our #IMPACC team members Leying (Lexi) Guan Jeremy Gygi Cole Maguire Ravi K. Patel for our newly published COVID-19 multiomics paper in JCI! Grateful to be working with all of you for the past few years!

Our collaborators develop modeling that helps identify multi-omic #immune #signatures #bioinformatics Leying (Lexi) Guan Steven Kleinstein 🖥 Jeremy Gygi Dr. Anna Konstorum + others pubmed.ncbi.nlm.nih.gov/38603606/

#ClinicalMedicine: Integrated longitudinal multiomics study identifies immune programs associated with acute #COVID_19 severity and mortality: buff.ly/3UUBKlO Leying (Lexi) Guan Yale School of Medicine #Immunology

Honored for our paper on heavy + light chain B cell tree building with Dowser to be picked as a #JI_TopRead!

I'm thrilled to share our new #Bioconductor package, nipalsMCIA, which performs multi-omic dimensionality reduction using the NIPALS algorithm. It is fast (especially for large datasets), and user friendly. Give it a try! biorxiv.org/content/10.110… (1/4)

Our collaborators plot an "immune health metric" that that can be applied widely. Authors include John Tsang @tsanglab.bsky.social Steven Kleinstein 🖥 Nature Medicine The IHM - recognizes marked #aging in healthy adults - measures age-dependent #antibody responses to #vaccines nature.com/articles/s4159…

We are excited to announce that the 3rd (Public) CMI-PB Challenge is officially underway! Test out your modeling skills to predict immune responses to B. pertussis #whoopingcough booster vaccination using multi-omics datasets for a chance to win. #bioinformatics #immunology (1/5)

I’m excited to announce that our paper on viral molecular mimicry just came out! Molecular mimicry occurs when pathogens “mimic” host protein structure. Here, we explore mimicry across the human virome and its connection to autoimmunity. Esther Melamed nature.com/articles/s4146…

Excited to share our latest #IMPACC study on patient subtype discovery using longitudinal multi-omics! We identified 5 subtypes among 1,000+ hospitalized #COVID19 patients, highlighting the link between distinct immune responses in those with similar respiratory status to various