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Some new information about the anti-inflammatory actions of GIP from Rola Hammoud, PhD Gain and loss of GIPR signaling modifies gut inflammation in mice with 5FU-induced enteritis, with data on Tirzepatide & Semaglutide JCI insight Banting & Best Diabetes Centre Sinai Health CIHR

Davide Croci, Sandra van Wilpe & Niven Mehra explain that analyzing combined biomarkers from circulating tumor DNA and immune cell gene expression data in blood predicts clinical benefit to immunotherapy in metastatic urothelial cancer: youtube.com/watch?v=9eigwf… Article:

ASCI member Fong et al. UC San Francisco show that JAK inhibition administered sequentially enhances anti-tumor immunity after combined anti-PD-1 and anti-CTLA4 therapy in pre-clinical prostate cancer study: insight.jci.org/articles/view/…

Check out our recent paper in JCI insight where we use interpretable #ML to uncover signatures of pathogenesis in localized #scleroderma (#morphea). insight.jci.org/articles/view/…

ASCI member Jonathan Brown @jonbrownlab et al. Vanderbilt Health identify that ZNF469—a zinc finger protein—regulates how scar tissue forms in the liver in response to fat accumulation: insight.jci.org/articles/view/… #MASLD #fibrosis

Cover article by Zhang and Jin shows that disrupting the CK2-PIAS1-SPOP signaling axis- including SPOP mutations as well as CK2/SPOP inhibitor-could increase the efficacy of PARP inhibitors, a targeted therapy, against prostate cancer: insight.jci.org/articles/view/…

Our new study by Adrian Zietara Lashodya Dissanayake Melissa Lowe Biyang Xu Vladislav Levchenko Chris Klemens Oleg Palygin just published JCI insight Potassium supplementation and depletion during development of salt-sensitive hypertension in male and female SS rats insight.jci.org/articles/view/…

This randomized-control trial show that giving the elderly high doses of influenza vaccine revealed immune responses similar to younger adults receiving the standard dose: insight.jci.org/articles/view/… Behazine Combadiere Inserm

.@mickymarinelli and team UT Austin designed and developed a PKCε small molecule inhibitor that reduces cancer chemotherapy-induced pain and prevents & reverses opioid withdrawal pain: insight.jci.org/articles/view/…

.Teppei Fujikawa 藤川哲兵 et al. UT Southwestern Medical Center generate a novel mouse model, Sf-1-Flp, and show its functional utility in addressing previously unapproachable questions about the ventromedial hypothalamic nucleus (VMH): insight.jci.org/articles/view/… Osaka Metropolitan University UTSW Internal Medicine UT Southwestern O'Donnell Brain Institute

Congrats to my incredible grad student Maggie Bohm for her manuscript in JCI insight entitled: The gut microbiome enhances breast cancer immunotherapy following bariatric surgery. A thread🧵

Cheng Ai et al. investigate the effects and therapeutic potential of VA supplementation in Leber hereditary optic neuropathy--an inherited form of vision loss–their findings may impact its precision diagnosis and treatment: insight.jci.org/articles/view/…

A new study from Accornero Lab The cardiac METTL3-m6A pathway regulates the systemic response to western diet insight.jci.org/articles/view/… The Ohio State University College of Medicine OhioStateDHLRI NIH NHLBI

2023 ASCI Emerging-Generation recipient Raul Olivares Glez. et al. University of Pittsburgh identify a novel target to manage treatment-refractory asthma by describing a significant association of airway CD8+ TEMRA cells with asthma duration: insight.jci.org/articles/view/…

👀 Check out this recent JCI insight publication from Dr. Richard Ramonell and members of PACCSM and Asthma & Environmental Lung Health Institute@UPMC that identified a new target to manage asthma🫁👇 #PittResearchMatters #PhysicianScientist

Haag et al. discover a novel metabolic signature to diagnosis lean MASLD early, potentially paving the way to explore new therapeutic interventions for this clinically underdiagnosed spectrum of liver disease: insight.jci.org/articles/view/…

Rhon-Calderon et al. UPMC show that IVF causes morphological and molecular defects in the male reproductive system & that adverse outcomes are transmitted to the next generation: insight.jci.org/articles/view/…

Remdesivir post-exposure prophylaxis limits measles-induced “immune amnesia” and measles antibody responses in macaques JCI insight insight.jci.org/articles/view/…

.Erin Giles, PhD Michigan Medicine show the beneficial effects of bazedoxifene+conjugated estrogens on metabolic health & also reduced the markers of breast cancer risk in a perimenopause and obesity rat model: insight.jci.org/articles/view/… Katherine L. Cook