High-plex protein and whole transcriptome co-mapping at cellular resolution with spatial CITE-seq go.nature.com/3koGTTC

One of the most detailed models of a human cell. Obtained using X-ray, and cryoelectron microscopy:

Thrilled to share my PhD work in Cell! Massively parallel base editing to map variant effects in human hematopoiesis. We developed screens on blood stem cells to understand disease and develop treatments at single-nucleotide resolution.1/n cell.com/cell/fulltext/…

Single-cell data from RNA-seq, chromatin accessibility, DNA methylation and other modalities can be readily integrated using two new methods #NBTNV go.nature.com/4222tNu

📢 Submit your abstract for the #CardiovascularRegeneration symposium University of Oxford on 13 — 14 September 2023. This event will highlight the recent developments in the field of cardiac regeneration & development. 📅 Submit by 30 June 🔗buff.ly/3OVi0fd

Gene regulatory networks (GRNs) are useful models to understand cellular identity and disease. We have reviewed the GRN inference field in the current era of single-cell multi-omics 📖 out in Nature Reviews Genetics 🔗doi.org/10.1038/s41576… Full-text access: rdcu.be/dfpa2

I am happy to communicate that SCENIC+ was published in Nature Methods. SCENIC+ is a workflow to infer enhancer-driven gene regulatory networks from scRNA-seq and scATAC-seq data. This work was done together with Carmen Bravo at @steinaerts lab! 🧵1/9🧵 nature.com/articles/s4159…

We have a research assistant position available to work with me and oliver stone. Join us to help set up in vitro models of human lymphatic endothelial cell development! Working in Department of Physiology Anatomy & Genetics (DPAG) at the Oxford_IDRM. Details: tinyurl.com/StoneGroupRA the Node #devbio #stemcells

🥳We are recruiting, please RT! I am delighted to advertise an exciting opportunity for a Senior Scientist with expertise in cardiovascular research and/or single cell informatics to join our team in EdinUniCVS, funded by British Heart Foundation. Please get in touch or follow the link below! 🫀

🌟🚨WE'RE HIRING🚨🌟 An incredible #postdoc opportunity, funded by the European Innovation Council 🇪🇺 to develop a novel human adenovirus for gene therapy in the brain or heart. Fixed term till April '27! elxw.fa.em3.oraclecloud.com/hcmUI/Candidat…

Human and murine fibroblast single-cell #transcriptomics reveal #fibroblast clusters are differentially affected by #ageing and serum cholesterol Discover more 👉academic.oup.com/cardiovascres/… European Society of Cardiology European Society of Cardiology Journals #scRNAseq #atherosclerosis #CardiovascularResearch

See link below for a 4-year postdoc in my lab in Edinburgh to study endothelial and platelet interactions in heart failure. This presents an exciting opportunity to travel and spend time in the laboratories of collaborators in the Netherlands and Germany. Please circulate!

Important reading nature.com/articles/s4155…

Nature research paper: Multimodal decoding of human liver regeneration go.nature.com/3wkmLb9

New pre-print from my lab, a useful resource for all interested in vascular gene regulation! We identify and characterise a cohort of mammalian arterial enhancers, alongside a re-examination of many previously reported endothelial enhancers Department of Physiology Anatomy & Genetics (DPAG) Oxford_IDRM

We are looking for a new team member. Please check it out, apply and spread the word #postdoc #cardiovascular #cambridge jobs.cam.ac.uk/job/48385/

Excited to share my work Riley Research Group, out today Nature Cardiovascular Research: nature.com/articles/s4416… Using imaging, scRNAseq & computational modelling , we find that the neonatal cardiac conduction system can regenerate & demonstrate how MI-induced damage elicits arrhythmogenesis 🫀⚡️ 🧵[1/n]

🚨 Come and join our team! I’m recruiting a Research Assistant to work on a British Heart Foundation funded project on the molecular regulation of epicardial EMT. Closing date 11th May 2025. my.corehr.com/pls/coreportal… Cardiovascular and Metabolic Medicine & Sciences King's BHF Centre King's Faculty of Life Sciences & Medicine #HeartDevelopment #Regeneration