CLINICAL COMMENTARIES: First-in-human #gene editing for lipid lowering: the initial results

Simon Tual-Chalot & Konstantinos Stellos, MD explore interim data from the Heart-1 trial & what this means for the future of lipid-lowering therapy
academic.oup.com/cardiovascres/…

#CVD #CardiovascularResearch

Initiation of Statins for Primary Prevention in #HFpEF

This New study including 7,970 Veterans with #HFpEF shows statins reduce mortality by 22% (HR: 0.78) & #MACE by 21% (HR: 0.79) over 6 yrs.

Also lowers all-cause hospitalization (HR: 0.69) & HF 🏥 (HR: 0.72).…

#BalanceDHF Milestone❗️

First pts enrolled in #BalanceDHF RCT studying unique #MRmodulator balcinrenone in combo w #SGLT2i dapagliflozin

Seeking to expand therapeutic options in HF+CKD across the full spectrum of LVEF!

Long way to go, but 💪🏾 global team
classic.clinicaltrials.gov/ct2/show/NCT06…

🎉 20 years celebrations! 🎉

I look back with pride and a real sense of achievement as the #HFA_ESC has grown from a group of enthusiasts to a large respected scientific community influencing the field of #heartfailure .

It's all thanks to YOU!

Celebrate with us: comment, share…

#EACVI Imaging Challenge 💫
Please vote for the best case

Anna Baritussio Robert Manka Elena Galli Hatem Soliman, FRCP, FEACVI, FASE, FHEA Henry Han Caroline Van De Heyning Gergely Ágoston Colin Monaghan Henry Han EHJCVI Editor-in-Chief

.JACC Journals reference pocket cards for contemporary global guideline recommendations for drugs & devices in HF across the LVEF spectrum.🗒️

jacc.org/doi/10.1016/j.…

Effects of #GDMT across Kidney Function Spectrum

✅ #BB : consistent benefit to eGFR 30
✅ #ARNI : consistent benefit to eGFR 30
✅ #SGLT2i : consistent benefit to eGFR 20
❌ #SteroidalMRA : ↓ benefit & worse safety at lower eGFR

New strategies to block MR axis in HF & CKD needed!

Rich pipeline of alternative approaches to safely block MR axis being investigated in heart & kidney disease

🔥 K+ lowering therapies
🔥 Nonsteroidal MRAs
🔥 MR modulators
🔥 Aldosterone synthase inhibitors

👀 this rapidly changing space—upcoming HF RCTs to likely report '24 👇🏾

Complexity & multi morbidity are the hallmarks of HFpEF

🎯 Addressing the single components of the picture seems to be the way for tailored treatment

#MedX #MedTwitter #CardioTwitter Radcliffe Cardiology Henry Han

Study finds elevated NT-proBNP levels in T2 #Diabetes patients indicate worse #HeartFailure and kidney outcomes, regardless of prior HF history. Higher risk with HF diagnosis. #CardiovascularRisk #CANVAStrial
Baim faculty James Januzzi Jr MD Javed Butler
doi.org/10.1016/j.card…

Association of #glycaemic index and glycaemic load with type 2 #diabetes , #cardiovascular disease, #cancer , and all-cause #mortality : a meta-analysis of mega cohorts of more than 100 000 participants thelancet.com/journals/landi… #T2D #CVD

This new finding from the #SwedishHF Registry shows #GLP1RA use to lower risk of #MACE in #HFpEF patients with DM.

📍GLP-1 RA use also a/w lower risk of CV and all-cause death in the same patient population.

📍Independent predictors of GLP-1 RA use include age<75, worse…

This is worth 10 minutes of your time, I promise: Jacob E Møller of Rigshospitalet and Sunil V. Rao hash over the #DanGerShock #MCS trial of #impella : is this controversy over benefits/risk been settled in #AMICS patients? TCTMD #ACC24 American College of Cardiology
tctmd.com/videos/on-reco…

Perfect 10 commands..... Thanks. clara saldarriaga Henry Han Luisa F. Aguilera Cynthia Paredes BiykemBozkurt Giuseppe Rosano

#Tirzepatide reduced sleep apnea severity by up to nearly two-thirds in adults with #OSA and #obesity

#GLP1 -RA #GIP -RA

What a pleasure to contribute to this working group and statement! European Society of Cardiology Journals

A roadmap for therapeutic discovery in pulmonary hypertension associated with left #HeartFailure . A scientific statement of the #HFA of the ESC and the ESC Working Group on Pulmonary Circulation & #RightVentricular Function

onlinelibrary.wiley.com/doi/full/10.10…
European Society of Cardiology Journals #HFA _ESC…

Fair Allocation of GLP-1 and Dual GLP-1–GIP Receptor Agonists

This perceptive introduces groundbreaking framework for fair allocation in healthcare, aiming to guide ethical decision-making within and among countries, ensuring equitable access for all

#GLP1 -RA #GIP -RA…

Overview of #multimodalityimaging in cardiomyopathy from Prof Steffen Petersen in #JSE #EACVI joint session

🔵Different modalities offer different benefits
🔵Echo (and CMR) remain the mainstay
🔵CMR tissue characterisation excellent in differentiating between different syndromes