Hypothermia brief overview

A mismatch between heat production and heat loss.

Body maintains core temperature at nearly 37 C to allow for optimized cellular metabolism, esp neuronal cells.

The most common causes via E3 mnemonic -
Exposure - cold environment (heat loss) or med…

Check out this gorgeous infographic from Simon Wu 🤩 #EndoTwitter Thiago

Curious about pheochromocytoma testing?
Simon Wu has got you covered with a video coming out 4/26/24!

Review the infographic below or at imfastfacts.com!

#MedTwitter #MedStudentTwitter #FastFactsFriday

Medical education is full of theories and studies, but nothing beats the 🪄 magic of making tough topics simple!

🔑 Simplification is everything!

This thought came after listening to Rabih Geha 6-min video about fragility fracture. Six minutes, meaningful!

🤔Osteomalacia x osteoporosis

I've just heard a simple and beautiful approach by Rabih Geha!

Osteoporosis: decreased bone mass, asymptomatic until a fracture occurs.

Osteomalacia: decreased bone mineralization, symptomatic; ⬆️ alkaline phosphatase.

rlrcpsolvers.com/schemas-script…

medical jargon:

“empiric” = I don’t know
“differential is broad” = I don’t know
“correlate clinically” = I don’t know
“poor historian” = he/she doesn’t know
“consult rheumatology” = who knows?

✅If you stop taking anti-hypertensives, what happens with blood pressure?

✅If you stop taking a medication for cholesterol, what happens with cholesterol?

🤔If you stop taking a medication for obesity, why would it be different?

You see someone with diabetes presenting to the ED with hypoglycemia.

Their blood glucose was in the 20s mg/dL. With glucagon and/or glucose, it rises to the 150s.

👉How do you decide on discharge x observation?

I’m curious about different approaches!

Re … stories when event rates are low.

Many years ago Milton Packer generously sat me down w his laptop (old and in need of cleaning) and explained the problem of low event rates.

Basically. We should be careful crafting stories with low rates of events.

I fear the…

🤔Ever heard of a drug that tackles both hypothyroidism and thyrotoxicosis emergencies by different mechanisms?

❗️Can you guess which drug and why?

No matter your field in medicine, this is a must-read!

Thoughts of the day:

When you think pheochromocytoma:

👉It’s probably not. Pheo is very rare!

👉 CT/MRI is not the initial workup. Diagnosis is biochemical!

Thought of the day

When meeting someone with type 2 diabetes for the first time:

- 2014: How to get A1c < 7%?

- 2024: How to get GLP-1 RA onboard?

🚨New Trial Results🚨
STEP-HFpEF DM

❤️🫀Semaglutide improved heart failure symptoms and physical limitations in pts with obesity, HFpEF and T2DM

⬇️ 6.4% weight over placebo
⬇️CRP
⬆️6 min walk distance

nejm.org/doi/full/10.10…

Not long ago, beta-blockers were used as the first-line treatment for hypertension. Not anymore.

Until yesterday, beta-blockers were part of the standard post-myocardial infarction therapy. Not anymore?

nejm.org/doi/full/10.10…

What situations can both decrease weight and increase insulin resistance?

- Hyperglycemia itself
- Thyrotoxicosis
- Pheochromocytoma
- Pancreatic cancer
- Acute pancreatitis (chronic causes insulin deficiency)

What else? Help me enlarging this list #MedX