You may never have heard of the plant Brassica Oleracea, but six vegetables you can find in any grocery store and you eat on a regular basis are actually all from this one plant and they're all human made products of selective breeding

In this blog post, I use our recent SEraster #Rstats tool to perform spatial bootstrapping to evaluate the stability of cell-type proportion estimates from #singlecell #spatialtranscriptomics data. Try it out for yourself: jef.works/blog/2024/07/2… #bioinformatics #codetutorial

"Virchow" computer vision model: significant progress using AI for cancer detection in tissues submitted from the clinic. So many possibilities! nature.com/articles/s4159…

Breakdown of the effects of major diets cell.com/cell/fulltext/… Cell Peter Turnbaugh Krista Varady

Now out - WebAtlas pipeline for visualizing and processing integrated single cell and spatial transcriptomics data ⁦Nature Methods⁩ ⁦Omer Ali Bayraktar⁩ ⁦Haniffa Lab⁩ ⁦Shila Ghazanfar⁩ ⁦Human Cell Atlas⁩ github.com/haniffalab/web… nature.com/articles/s4159…

Inferring histology-associated gene expression gradients in spatial transcriptomic studies ⁦Nature Communications⁩ nature.com/articles/s4146…

New nature The largest study of impact of dietary restriction (DR) in ~1,000 mice with diverse genetic background for health and lifespan nature.com/articles/s4158… —40% caloric restriction had the most lifespan expansion effect but suppressed immune response and loss of lean

Biggest medical discoveries of the week (🧵) 1/10 Why does caloric restriction boost lifespan? This study of ~1,000 mice finds (surprisingly) it's less to do with lowering fat mass, and more to do with boosting immune function and stress resilience nature.com/articles/s4158…

DIPG is… 1/2 DIPG is being ignored by your GP. “Your son does not have a brain tumour.” Because he’s never heard of it. Because it’s not well known.

A huge day for spatial omics of cancer, tracing the precise origin and evolution of 20 types of cancer, many in 3D, in ~2,000 individuals, with 12 publications nature Nature Cancer Nature Medicine Nature Methods Communications Biology Collection nature.com/immersive/d428…

Need to design your next Xenium/CosMx/Merfish experiment? Spapros, now out Nature Methods, allows for probe set selection for target spatial tx. Led by Louis Kuemmerle, it optimizes both cell type ID & within-cell type variation. nature.com/articles/s4159… github.com/theislab/spapr…

Rosettes and Pseudorosettes : In Pictures 🔬🌸 ditki.com/course/patholo…

New images available! NCI’s Imaging Data Commons now contains tumor and tissue images from nearly 2,000 children participating in the Molecular Characterization Initiative. Check it out! go.nih.gov/1JgGgWw #Data4ChildhoodCancer #ChildhoodCancer #CancerResearch

🐭Robust acute myeloid leukemia engraftment in humanized scaffolds using injectable biomaterials and intravenous xenotransplantation 👉buff.ly/4jB1jTe #LYLSM #CancerModels #PDXs

Last year, $9B of the $35B that the National Institutes of Health (NIH) granted for research was used for administrative overhead, what is known as “indirect costs.” Today, NIH lowered the maximum indirect cost rate research institutions can charge the government to 15%, above

From cells to DNA, we show everything to scale. Learn more at smart-biology.com #biology #3D #science #EdTech

We trained a genomic language model on all observed evolution, which we are calling Evo 2. The model achieves an unprecedented breadth in capabilities, enabling prediction and design tasks from molecular to genome scale and across all three domains of life.

These Captchas are getting out of hand 🤓

NEW STUDY: Intermittent fasting (IF) significantly alters the microbiome of mice, with reductions in the gut production of obeticholic acid, a bile acid that induces expression of gut-derived hormones, and an increase in N-acetylglycine production Why is this interesting? 🧵

Predicting gene expression from DNA sequence using deep learning models nature.com/articles/s4157… (read free: rdcu.be/elSrE) 🧬🖥️🧪