Cancer cell-intrinsic mechanisms driving acquired immune tolerance: Immune evasion is a hallmark of cancer. Ghorani, Swanton, and Quezada discuss the mechanisms whereby cancer cells avoid immune recognition and destruction and present a conceptual framework that places these

Our new #preprint is out on #bioRxiv! Applying #spatial transcriptomics at subcellular resolution to 95 ovarian #cancer tumors, followed by high content #CRISPR screens, we identified immune evasion drivers at the genetic, cellular, and tissue level doi.org/10.1101/2023.1… (1/13)

High-dimensional deconstruction of pancreatic cancer identifies tumor microenvironmental and developmental stemness features that predict survival nature.com/articles/s4169…

ICYMI: Spatial Positioning and Matrix Programs of Cancer-Associated Fibroblasts Promote T-cell Exclusion in Human Lung Tumors by Hélène Salmon featuring #TumourLandscape23 speaker Miriam Merad, MD, PhD-out in Cancer Discovery doi.org/10.1158/2159-8…

Computational immunogenomic approaches to predict response to cancer immunotherapies nature.com/articles/s4157…

'Cancer-associated fibroblasts actively compress cancer cells and modulate mechanotransduction' nature.com/articles/s4146…

Temporal genomic analysis of melanoma rejection identifies regulators of tumor immune evasion biorxiv.org/cgi/content/sh… #biorxiv_cancer

New #OpenAccess Trends in Cancer review from Neta Erez- ErezLab🎗️ Lea Monteran Yael Zait It’s all about the base: stromal cells are central orchestrators of metastasis cell.com/trends/cancer/… The trinity of fibroblasts, osteoblasts and astrocytes play pivotal roles in each step of the

Nice work from our recent MD/PhD student who shows how melanoma cells travel along blood vessels within the brain microenvironment. Congrats to Sarah! nature.com/articles/s4141…

While not adequately acknowledged, the dysregulated extracellular matrix plays a pivotal role in cancer. Here's a new, brilliant review on it Science Translational Medicine science.org/doi/10.1126/sc… w/ great Science Visuals

Thanks for including me on this wonderful paper MarineLab, examining the melanoma cell states that confer intrinsic resistance to immunotherapies. sciencedirect.com/science/articl… Cell Yale Dermatology Yale School of Medicine

My emotional COI here is taller than the Burj Khalifa. With that disclosure: nature.com/articles/s4158… behold beautiful work by the brilliant Jennifer R Hamilton @doudna_lab Institute for Geographic Information Science on what I personally think will be THE paradigm for immune system genome editing for both oncology and

It has been a long journey but our perspective "Linking cell mechanical memory and cancer metastasis" is finally out! Many thanks to my co-authors, my mentor Roger D Kamm, and the incredible team of Nature Reviews Cancer for contributing to bringing this article to light.

New resource report in the January 15th issue— Integration of #PanCancer #SingleCell and Spatial Transcriptomics Reveals Stromal Cell Features and Therapeutic Targets in Tumor Microenvironment, by Yanhua Du et al. bit.ly/3S8d3j5

nature.com/articles/s4146… Our most recent study on resistance to ICB in melanoma is out now Nature Communications ! Great collab. with CCIT-DK: National Center for Cancer Immune Therapy Marco Donia Joan_Yuan_Lab KPietraslab . Medicinska fakulteten, Lunds universitet Lunds universitet Cancerfonden KAW

More evidence that the liver & pancreas are in active communication in the setting of #PancreaticCancer. There is published data already on how the primary pancreatic cancer alters the pre-metastatic niche in the liver (see next tweet). But how does the liver clap back? Nice

Our latest nature paper is out! We show that transplanting mitochondria into endothelial cells boosts their ability to form blood vessels in ischemic tissues, with mitophagy as the key mechanism. A potential game-changer for vascular cell therapies. nature.com/articles/s4158…

Reprogramming endothelial cells to empower cancer immunotherapy - check out the opinion article from Penn Abigail H. Cleveland & Yi Fan in Trends in Molecular Medicine #AAI2024 hubs.li/Q02vSy9Q0

12/ HUGE shout out to our incredible team led by Kristina Whately Nisitha Sengottuvel, MD, PhD Lincy Edatt Sonal 👏 Fantastic collaborators DrewDudleyLab Amelio Lab Appreciate the reviewers' efforts and the editorial staff at JCI insight who were great! LungCancerInitiative @NCICancerBio Lung Cancer Research Foundation

Components of normal tissue architecture maintain structure (+ fxn) & serve as barriers to tumor progression…but how? We report a 🧩 in our new preprint. Congrats to 1st author @kathrinaonate & thx to collabs Memorial Sloan Kettering Cancer Center OHSU Knight Cancer Institute Stanford Medicine! 1/ biorxiv.org/content/10.110…