Sex Differences in Cognitive Decline Among US Adults. These findings suggest that women may have greater cognitive reserve but faster cognitive decline than men. | JAMA Network bit.ly/3vWcc95 Dr. Jennifer Manly Kristine Yaffe UCSF Center for Population Brain Health (K. Yaffe) JAMA Network Open

Are women more resilient than men after PD diagnosis? 'Most frail PD men die rapidly before receiving a dementia diagnosis, whereas women with PD survive at higher rates, regardless of their age at onset and disease severity.' BOOM! …mentdisorders.onlinelibrary.wiley.com/doi/10.1002/md…

The pattern for parental transmission of Alzheimer's disease to offspring is different for mothers compared with fathers, but the reason(s) for this is not yet understood jamanetwork.com/journals/jaman… jamanetwork.com/journals/jaman… JAMA Neurology

Blame Mom? β-Amyloid in Cognitively Unimpaired Individuals. Check out my Editorial with Holly Elser JAMA Neurology #Alzheimers jamanetwork.com/journals/jaman… jamanetwork.com/journals/jaman… Original Article by Mabel Seto Rachel Buckley 🐨🇦🇺🐨

Today the JAMA Neurology Editorial Board met to discuss plans for the journal, which is dedicated to publishing scientific information for physicians caring for people with neurologic disorders and those interested in the structure and function of the human nervous system.

Tau imaging predicts conversion to dementia.

A tour de force study on biological aging of 9 organs through genomic variants from over 377,000 UK Biobank participants Predominant organ-specific variants but much organ crosstalk pointing to causal relationships (no organ system is an island) nature.com/articles/s4358…

Excited to share our new study where we discovered a new form of B12 deficiency that cannot be detected on standard blood tests. (1/6) Pleasure Lab UCSFNeuroRes Sravani Kondapavulur Michael Haney Andoni I. Asencor Eoin Flanagan science.org/doi/10.1126/sc…

Online now!✨RESEARCH: Wen et al characterize the genetic architecture of the biological age gap of different organs, using machine learning and multimodal UK Biobank data Junhao (Hao) Wen #Multiorgan #AI #ML #BAG nature.com/articles/s4358… rdcu.be/dMbNO

Sex-dependent APOE4 neutrophil–microglia interactions drive cognitive impairment in Alzheimer’s disease | ⁦Nature Medicine⁩ nature.com/articles/s4159…

Electronic health records have huge potential to provide clinical insights for populations and individuals; Marina Sirota & colleagues discuss the opportunities and challenges, with an emphasis on reducing bias UCSF Bakar Computational Health Sciences Institute Marina Sirota #precisionhealth nature.com/articles/s4159…

Check out this tour de force review on Sex Differences in Resilience in #Aging and #Alzheimers spearheaded by Eider Arenaza-Urquijo. Women show advantage in cognitive resilience and reserve in aging and this advantage diminishes in AD when they eventually show faster cognitive decline.

Check out our lastest! A second X chromosome improves cognition in aging male and female mice. Spearheaded by Francesca Marino. biorxiv.org/content/10.110…

Nearly half of dementia cases could be prevented or delayed by tackling 14 risk factors starting in childhood, including two new risks—high cholesterol and vision loss, suggests new report from the Lancet Commission on dementia. Find out more ➡️ hubs.li/Q02KbpYf0

Nice paper published with comments from me. Blood test uses ‘protein clock’ to predict risk of Alzheimer’s and other diseases nature.com/articles/d4158…

By multiple molecular marker (omic) assessments, aging is a non-linear process with key transition points around 40 and 60 years of age nature.com/articles/s4358… Nature Aging

The 5 different patterns of brain aging from ~50,000 individuals, with their relationship to lifestyle, genetics and outcomes, derived from MRI and #AI. nature.com/articles/s4159… Nature Medicine Christos Davatzikos and colleagues

Evidence from omics that aging is not a gradual, linear process. The new study, highlighted here, only assessed people up to age 75 among 108 participants with short term follow-up (1.7 yrs). A previous large study (N>4,200, up to age 95) found a 3rd peak at age 80.

#NewIssue Ft cover art by Kehuitang Art Studio. He et al. reveal a protective effect of acetate against metabolic and cognitive impairments caused by sleep disruption. Inspired by Monet’s famous Water Lilies paintings, a “mitochondrion” boat drifts in a lotus pond full of water

What slows or speeds brain aging? This is just 1 of 10 recent papers in today's nature nature.com/articles/d4158… This one along with the others are reviewed in the new Ground Truths, link in my profile