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our work on the molecular differences between transcription factor isoforms is out now in Molecular Cell! key point: 2/3rds of TF isos differ in important properties like DNA binding & transcriptional activity many are "negative regulators" that are misexpressed in cancer

We are hiring a person to join our team at the Seattle Hub for Synthetic Biology. Please share the word! Link to apply: alleninstitute.org/careers/jobs/?…

Interested in single cell genomics but need help getting started? Check out the full agenda for our Single Cell Genomics Day on Friday 4/25. All talks will be live-streamed (no registration required) at satijalab.org/scgd25

In dire times clone dire wolves

Reprogramming site-specific retrotransposon activity to new DNA sites nature.com/articles/s4158…

'Extrachromosomal DNA — Amping Up Cancer' in NEJM! Lillian Siu & Trevor Pugh Pugh Lab highlight the encyclopaedia of ecDNA published in nature by Charles Swanton in collaboration with team eDyNAmiC 🔗nejm.org/doi/full/10.10…

Rewriting regulatory DNA to dissect and reprogram gene expression: Cell cell.com/cell/fulltext/…

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Long-range massively parallel reporter assay reveals rules of distal enhancer-promoter interactions biorxiv.org/content/10.110…

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New online! Genomics of schizophrenia, bipolar disorder and major depressive disorder bit.ly/455kG1G

Three-dimensional genome landscape of primary human cancers nature.com/articles/s4158… #journals #feedly

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Today in Science Magazine we report the development of a laboratory-evolved CRISPR-associated transposase (evoCAST) that supports therapeutically relevant levels of RNA-programmable gene insertion in human cells, a collaboration with Sternberg Lab. 1/13 drive.google.com/file/d/1I-UbCR…

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🚨 We're hiring! NYU Langone is seeking an Assistant Research Technician to support cutting-edge transgenic mouse research. Join a world-class team advancing science & medicine. 🧬🐭 📍 NYC | 💼 Full-time | 📎 Apply now: bit.ly/45rYI9e #LabJobs #BiotechCareers

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