#slidearchiveseries metastatic mixed germ cell tumor (teratoma and choriocarcinoma) involving lymph node #gupath

🏥 h/o testicular mixed germ cell tumor (teratoma, choriocarcinoma, seminoma) s/p chemotherapy and RPLND with growing mediastinal mass and increasing HCG

#slidearchiveseries eosinophilic solid and cystic renal cell carcinoma #gupath #pathtwitter #pathoutpic

🔬 solid and cystic architecture, basophilic intracytoplasmic stippling, and eosinophilic inclusions
🎨 PAX8+, frequently CK20+, usually CK7-/CD117-, majority Cathepsin K+

#slidearchiveseries urothelial carcinoma, clear cell (glycogen-rich) #gupath #pathtwitter #pathoutpic

🎨 IHC profile similar to conventional urothelial carcinoma (GATA3, p63)
⚠️ distinguish from metastatic CCRCC and clear cell adenocarcinoma