Excited to share our #multiomics study of who was the world's #oldest living person! Our research on this record-breaking #supercentenarian suggests that, under certain conditions, #aging and #disease can become decoupled—challenging the common belief that they are inherently

Great accomplishment!!

Incorporating Circulating Tumor DNA Testing Into Clinical Trials: A Position Paper by the National Cancer Institute… pubmed.ncbi.nlm.nih.gov/40048671/ Glad to see this finally come out from the National Cancer Institute #NCTN ECOG-ACRIN Cancer Research Group SWOG Cancer Research Network Alliance for Clinical Trials in Oncology NRG Oncology co-authors! #ctDNA #CancerResearch #Cancer

🚨Thrilled to share our latest work: “Tumor-Infiltrating Clonal Hematopoiesis” NEJM - we investigated how age-related blood mutations impact cancer when they infiltrate tumors, with Elsa Bernard Maria Zagorulya, Elli Papaemmanuil, PhD Charles Swanton + more nejm.org/doi/full/10.10…

Lessons from top leaders in pharma & surgery: •Adaptability + resilience = key to success •Serendipity shapes discovery •Find mentors you admire •Forge your own path, not just the expected one •Persevere daily & protect what matters most (family!) #WICR #AACR25

One of the best parts of #AACR25 is reconnecting with old mentors. Grateful for the conversations, encouragement, and reminders of how far we’ve come — and how much there’s still to do. #Networking #Mentorship

Scientific papers funded by NIH will publish online for free at the same time as in paywalled scientific journals. The grift of charging people to read the results of studies they already paid for is over. Interesting to read which journals lobbied against this: The trade group

The Single-cell Analytics Innovation Lab Memorial Sloan Kettering Cancer Center is looking for ML-oriented computational biologists. Join our team based in NYC to work on cutting-edge single-cell & spatial transcriptomics methods in collaboration with leading research labs. bit.ly/4lTEr2t

New data from the BREAKWATER trial shows triplet therapy (encorafenib + cetuximab + chemo) doubles overall survival in patients with BRAF V600E–mutated metastatic colorectal cancer. Median OS: 30.3 vs. 15.1 months. #ASCO25 #EndCancer ASCO NEJM Scott Kopetz spr.ly/6018NfDE0

Today, as we recognize and celebrate Juneteenth, the AACR highlights the importance of research to understand and address the many factors that contribute to cancer health disparities, from biological to socioeconomic drivers of inequitable outcomes. brnw.ch/21wTwHE

I'm thrilled to share our new study out in Nature Medicine! We show that a blood test can estimate how aged or youthful one’s organs are and that these organ ages predict future disease and lifespan. Final paper from my PhD in the Tony Wyss-Coray lab. 🧵1/12 🔗 nature.com/articles/s4159…

Excited to share a milestone published in Nature Medicine from our decade-long effort to build The Human Phenotype Project, a unique longitudinal cohort with unmatched depth of clinical and multi-omic profiling, enabling truly predictive, personalized medicine. Led together with

Clonal hematopoiesis (CH) is when blood cells carry mutations. It’s common with age—and sometimes a warning sign for cancer. But not all CH is equal. Why do some people progress, and others don’t? Check out Kelly Bolton MD PhD’s excellent thread and our paper here Nature Genetics 👇

‘Congress has your back’: US senators tell scientists they want to protect NIH budget. I am confident that the House will agree. nature.com/articles/d4158…

Despite its rising incidence 📈 and poor outcomes, we still have a limited understanding of the biology driving early-onset colorectal cancer (<50y). Most prior studies were small, inconsistent, or confounded by MSI and treatment exposure. In JCO OA, Futreal, Scott Kopetz , and

New preprint alert: tinyurl.com/tenk10k-multio…. Excited to share our analysis on the impact of genetic variants on single-cell chromatin accessibility in blood, using scATAC-seq and WGS from over 1,000 donors and 3.5M nuclei as part of TenK10K phase 1 🧬 🧵👇 (1/n)

✨ Applying for fellowships? Check out 40+ successful sample applications from: NSF-GRFP, PD Soros, HHMI Gilliam, Ford, NIH F31 …and more! Get inspired and strengthen your own application by learning from winners in your field. 🔗 cientificolatino.com/writing-center

Excited for the future of cancer research! Congratulations to my former PI, Anthony Letai MD PhD on being sworn in as NCI Director — a leader whose strength, vision, and commitment to asking the right questions have left a lasting mark. nih.gov/news-events/ne…

Students, trainees, and researchers — don’t miss the chance to showcase your work at Broad Institute #MachineLearning in #DrugDiscovery Symposium, and network with leaders across academia and industry! Deadline Oct 3rd! Register: broad.io/mldd and submit an abstract!

Once again, the immune system grabs the Nobel spotlight. Brunkow, Ramsdell & Sakaguchi’s groundbreaking research on peripheral immune tolerance reshaped our understanding of autoimmunity & immune therapies. linkedin.com/redir/redirect…