1st lumateperone (Caplyta) RCT in major #depression :
> Aug #antidepressants , medium effect size (0.6)
> 6 wks, 485 pts, 1-2 failed med trials
> Fatigue, dry mouth, tremor main side effects

Data unpublished, summary here:
ir.intracellulartherapies.com/news-releases/…

2nd trial anticipated in summer.

A popular DIY (home-based) therapy for depression (transcranial direct current stimulation) is tested in ADHD #mentalhealth thecarlatreport.com/articles/4665-…

PEA improved post-COVID olfaction in 6 RCTs, and lifted post-COVID depression/fatigue in new comparative trial (small, not randomized)
pubmed.ncbi.nlm.nih.gov/38381905

It has small RCTs in #depression , #bipolar mania, #migraine , #pain .

Learn how to use it:
moodtreatmentcenter.com/products

We need a little help in figuring out if [our kids are] simply developing at a slower pace, or if they could be showing signs of autism Positive Development positivedevelopment.com/blogs/top-sign…

New podcast with Joshua D Feder and Mara Goverman, LCSW: What steps should clinicians take if psychopharmacologic treatments and school behavioral strategies are insufficient for managing ADHD in children? Learn more about the ADHD Algorithm at thecarlatreport.com/blogs/2-the-ca…

Silexan (lavender extract approved for anxiety in Europe) is more effective than SSRIs in head-to-head trials & worked better for more severe #anxiety in new analysis of 5 RCTs:
pubmed.ncbi.nlm.nih.gov/38425206

Podcast:
thecarlatreport.com/blogs/2-the-ca…

How to use:
moodtreatmentcenter.com/products

First case of ketamine tolerance from Mayo Clinic:
pubmed.ncbi.nlm.nih.gov/38597410

To stay well, the patient required increasing frequency of #ketamine , until it no longer worked after 5 years.

#depression #psychiatry

Incarcerated individuals with opioid use disorder are at an especially heightened risk of adverse outcomes.  The period immediately following release is a particularly vulnerable time, with an elevated risk of fatal overdose. #mentalhealth thecarlatreport.com/articles/4617-…

Two psych meds held promise for #COVID : lithium and fluvoxamine, an #SSRI antidepressant. So far, the data favors #lithium :
ncbi.nlm.nih.gov/pmc/articles/P…

but not the SSRI:
pubmed.ncbi.nlm.nih.gov/37002592

#psychiatry

ADHD in adults ti.ubc.ca/2023/09/29/144… Therapeutics Initiative #mentalhealth

'Psychopathological phenomena don’t always indicate complete dysfunction. Similar to issues in general medicine, mental health problems involve a mix of function and dysfunction' -Awais Aftab. Our EIC Mark L. Ruffalo speaks with Dr. Aftab. Enjoy! thecarlatreport.com/articles/4674-…

Update on #MDMA :
1. Large effect in #PTSD assisted therapy (full remission in 61-71%)
2. Preliminary trials in #autism , social #anxiety , #alcohol use disorder
3. All trials from the same company (Lykos/MAPS)

From a review by Owen Scottt Muir, MD, DFAACAP et al:
pubmed.ncbi.nlm.nih.gov/38518271

What do you look for to diagnose Fetal Alcohol Spectrum Disorder (FASD)? Dr. Ira Chasnoff describes the broad impact of FASD and what to look for in the patient’s history (hint: you usually won’t see facial stigmata). #psychiatry #mentalhealth thecarlatreport.com/articles/4648-…

Curcumin & omega3 improve #depression , #diabetes (DM).

New trial tested them in DM: benefits in some but not all metabolic markers. Not clear if passes corrections for multiple measures.
pubmed.ncbi.nlm.nih.gov/38589346

Learn how to use them in depression
moodtreatmentcenter.com/products

Borderline patients in the 'vindictive problem pattern' self-reported lower functional disturbances, though they remained significantly clinically impaired. In other words, vindictive borderline patients underestimate the severity of their impairment.

N-acetylcysteine (NAC, 2400 mg/d) reduced #nicotine #smoking in a small randomized trial:
pubmed.ncbi.nlm.nih.gov/38500894

The antioxidant has mixed results in substance/mood disorders. It prevented #lithium renal toxicity in animal studies. Learn how to use it:
moodtreatmentcenter.com/products

FDA cleared Rejoin, 1st app for #depression , based on a large trial that failed on primary outcome but was positive on secondary outcomes:
rejoynhcp.com/Clinician-Brie…

Combines #CBT w/ emotional training game designed to improve recognition of facial expressions. Release = Summer '24

What's the future for #alcohol use disorder?

Besides FDA-approved ones below, review finds varying support for baclofen, ondansetron, gabapentin, topiramate, #psychedelic #therapy , ibudilast, GLP-1 agonists, GHB, and TMS:
ncbi.nlm.nih.gov/pmc/articles/P…

#sober #sober life #recovery

New for #alcohol use d/o: Cyproheptadine+Prazosin. The combo reduced drinking in RCT of 154 (3 mth, medium effect)
pubmed.ncbi.nlm.nih.gov/38597214

Cyproheptadine is similar to mirtazapine and has small trials various psych disorders. Prazosin a blood pressure medicine used in #PTSD .

Updates on #psychedelics :
1. Impressive preliminary results: #psilocybin in #Alcohol UD; #DMT in #Depression
2. Enduring benefits in some trials
3. Low drop out rates
4. High dose, chronic or recreational use = dangerous

From new review:
pubmed.ncbi.nlm.nih.gov/38518271

Art: Roger Dean