Chris Aiken, MD
@chrisaikenmd
Editor-in-Chief: Carlat Psychiatry Report. Director: Mood Treatment Center. Never received pharma funding. Posting a daily dose of practice-changing research.
ID:1536098282929258500
http://www.moodtreatmentcenter.com 12-06-2022 21:29:27
2,1K Tweets
5,0K Followers
969 Following
New use for fluoxetine (Prozac).
It treated refractory bed-wetting in children in this RCT, but the benefit declined over time (in primary monosymptomatic nocturnal enuresis):
pubmed.ncbi.nlm.nih.gov/36043350
Need to weigh against risks of antidep in children
#psychiatry #Pediatrics
1st lumateperone (Caplyta) RCT in major #depression :
> Aug #antidepressants , medium effect size (0.6)
> 6 wks, 485 pts, 1-2 failed med trials
> Fatigue, dry mouth, tremor main side effects
Data unpublished, summary here:
ir.intracellulartherapies.com/news-releases/…
2nd trial anticipated in summer.
Review lists saffron's results from small, randomized trials:
> Beat placebo in #depression , cognition, insomnia
> Equaled standard meds in #anxiety , #ADHD , #OCD
> Well tolerated
pubmed.ncbi.nlm.nih.gov/38424688
Recommended products (surprisingly, low cost):
moodtreatmentcenter.com/products
Antipsychotics are often used for #delirium , but you have to look hard to find evidence that they work.
You won’t find it in this analysis of olanzapine (Zyprexa):
pubmed.ncbi.nlm.nih.gov/36845642
#psychiatry #antipsychotic #medicine
Silexan (lavender extract approved for anxiety in Europe) is more effective than SSRIs in head-to-head trials & worked better for more severe #anxiety in new analysis of 5 RCTs:
pubmed.ncbi.nlm.nih.gov/38425206
Podcast:
thecarlatreport.com/blogs/2-the-ca…
How to use:
moodtreatmentcenter.com/products
The first placebo-trial of low-dose #lithium for cognitive impairment came out 12 years ago, and this study followed up on 59% of the cohort:
ncbi.nlm.nih.gov/pmc/articles/P…
Benefits were sustained, even after stopping lithium.
#memory #psychiatry #neurology
First case of ketamine tolerance from Mayo Clinic:
pubmed.ncbi.nlm.nih.gov/38597410
To stay well, the patient required increasing frequency of #ketamine , until it no longer worked after 5 years.
#depression #psychiatry
Clonidine treats ADHD, but does it help cognition in #schizophrenia ? A new, small RCT suggests yes, as do a series of studies with the similar med guanfacine:
sciencedirect.com/science/articl…
Clonidine also helps psychogenic polydipsia, common in psychosis