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The Academy of Health & Lifespan Research (AHLR) is proud to announce the publication of our first white paper in Nature Aging. As a global society of leading scientists, AHLR is dedicated to advancing geroscience—the study of aging as a biological process that can be slowed or

90% of chronic disease linked to our environment. Comment in Nature Medicine posits understanding “how” is now possible w/ clinics & communities acting as real-world testbeds. Welcome to Human Exposome Project. Congrats @FurmanBios rdcu.be/edgxZ pressreleases.responsesource.com/news/106243/of…

New Buck blog! #geroscience hypothesis posits #aging is root cause of many chronic diseases. Targeting aging process could delay or prevent these conditions. This hypothesis being tested in tiny nematode worms and preliminary results are intriguing! buckinstitute.org/blog/unravelin…

Big breakthrough in #Parkinsons research could lead to new treatments. Study in Science Magazine visualizes #PINK1 for the 1st time and shows how it binds to mitochondria. Mutated PINK1 disrupts mitophagy which leads to cell death. science.org/doi/10.1126/sc…

Study in Nature Aging zeros in on #inflammation as a driver of #Alzheimers. Researchers detailed the precise mechanism through which IL-12 damages mature oligodendrocytes and interneurons, important for memory and cognition nature.com/articles/s4358…

Linoleic acid is the most abundant polyunsaturated fatty acid in the Western-style diet and has been implicated in promoting inflammation and cancer. In Science, researchers report a mechanism by which linoleic acid can activate the mTORC1 protein kinase, which coordinates

In Science Signaling, researchers interrogate the mechanisms of neuroinflammation in mice and tie the process to a pathway involving microglia and the enzyme GCN5, hinting that this factor could potentially be a new therapeutic target. 📄: scim.ag/4iqtZww

Say no to sodas! Study in The Journal of Nutritional Biochemistry details how excessive #sugar impacts specific organs. Example: excessive consumption causes a “molecular addiction” in the intestines, favoring the absorption of sugar over other essential nutrients. sciencedirect.com/science/articl…

Great seminar at the Buck today with speaker, Assoc Prof Jessica Young from @uofwa She discussed risk factors and molecular culprit of Alzheimer’s Disease.

How much more evidence do you need? Study in Nature Medicine shows those who eat “healthy” in midlife are more likely to have a healthy old age. Data involved 105,000 people tracked over 30 years. Check out optimum diet here: nature.com/articles/s4159…

This finding could lead to treatments for neurological diseases go.nature.com/4iSo9o6

Researching #cellularsenescence? Study in Nature Communications highlights new open-source software that can find senescent cells in organs and tissues. Scientists University of Illinois Chicago identified 72 mouse and 64 human signatures in various organs nature.com/articles/s4146…

A new blood test for #Alzheimers aids in diagnosis also indicates how far disease has progressed. Study in Nature Medicine shows levels of MTBR-tau243 correlates with disease severity. New test could help ID patients likely to benefit from drug treatment. nature.com/articles/s4159…

Latest report from annual Biomarkers of Aging conference in Nature Aging offers potential next steps for BOA Consortium and larger research community. Takeways: Need for longitudinal data and analysis pipelines. Buck was happy to be a part of it. nature.com/articles/s4358…

Is this why postmenopausal women experience more pain? Study in mice in Science Magazine shows female hormones make immune cells near the spinal cord produce opioids stopping pain signals before they get to the brain. A new approach for treating pain? science.org/content/articl…

Marking The National Institute on Aging (NIA) 50th anniversary Driscoll, Lithgow & Phillips review #Caenorhabditis Intervention Testing Program. Conducting >725,000 animal assays over 891 trials CITP ID’d robust & reproducible interventions that extend lifespan. Which ones worked? link.springer.com/article/10.100…

🥵🥶In a perspective, Bruno Conti and Rafael de Cabo discuss the mechanisms by which lowered body temperature prolongs lifespan and contributes to the effects of calorie restriction - online now! nature.com/articles/s4358… rdcu.be/eg1Ur

Hope for #osteoarthritis pain? Study in nature uncovers > than 900 genetic associations, 10% of genetic targets linked to already approved drugs. Study could support personalized treatments and ID’s 8 key biological process crucial to disease development nature.com/articles/s4158…

Fascinating talk today at Buck by speaker Dr. Saul Villeda from @ucsf. He talked about work on blood-based approaches to rejuvenate the brain.

Mining UK Biobank allows Buck researchers to link findings in simple animals to human health. It also helps direct research in model organisms as they attempt to identify mechanisms that drive aging and disease in humans. Pretty cool! Read latest blog: buckinstitute.org/blog/buck-rese…