Through a @Hevolution_f and AFAR grant, Alex Bick, of Vanderbilt University Medical Center will research 'Identifying Clonal Hematopoiesis Resiliency Mechanisms.'
Learn more here: afar.org/grantee-profil…
#stemcells #DNA #Clinical #humangenome #Longevity

Thrilled to have completed the Nashville Half-Marathon✅
Each mile was a testament to endurance and the incredible community cheering us on. Feeling accomplished and inspired! 🏅🏃‍♂️ #NashvilleHalf

Excited to share our manuscript in Nature Communications looking at the clinical consequences of a polygenic predisposition to benign lower white blood cell (WBC) counts.
Vanderbilt Genetics Institute VUMC Department of Medicine DBMI at Vanderbilt University Vanderbilt Hem / Onc
doi.org/10.1038/s41467…

Save the Date! Pls join us Vanderbilt-Ingram Cancer Center #Stemcell Transplant #Cellulartherapy Symposium with a fantastic group of speakers! Adetola Kassim Muhamed Baljević, MD, FACP Somedeb Ball Bhagirath Dholaria, MD Eden Biltibo Ashwin Kishtagari, MD Carrie Kitko, MD (she/her) Ola Oluwole #cancer #CancerResearch

spr.ly/6014wA4Ce

BCR::ABL1 Kinase N-lobe Mutants Confer Moderate to High Degrees of Resistance to Asciminib ashpublications.org/blood/article-…

Delighted to share our new work in Journal of Clinical Oncology on CH and associated therapy-related leukemia in HL patients undergoing autologous transplant-with implications for screening and follow-up
ascopubs.org/doi/10.1200/JC…

Tagraxofusp is a first-in-class CD123-directed drug which has changed the field of #BPDCN . We review the evidence leading to its approval, use in combos and newer CD123 agents.
Wei Ying Jen Naveen Pemmaraju, MD Marina Konopleva MD Anderson Cancer Center #Leukemia
ACS Journal Cancer
doi.org/10.1002/cncr.3…

We're excited that Nature Reviews Genetics is now publishing a new article type called 'Tools of the Trade' in which early career researchers - graduate students, postdocs or new PIs - can discuss their new method, tool or technique #NRGToT #ToolsoftheTrade 🧰🛠️

Tune in to our new episode on diagnosis and management of Essential Thrombocythemia with Raajit Rampal, M.D.Ph.D.!
tinyurl.com/yfzst3cw
Here is a clip on what to do with 'platelet millionaires'?
Ashwin Kishtagari, MD Eddie Cliff Raj Chakraborty
#mpnsm

Excited to share our latest study published in Blood Advances on Clonal Hematopoiesis and Inflammation in the VasculaturE (CHIVE): a prospective, longitudinal cohort and biorepository at Vanderbilt University Medical Center

➡️ In this preliminary dataset, we've enrolled 181 CH/CCUS pts. Key

Jūmonji (十文字) isn’t the same as Jumanji.

PubMed now prompts people who search there for Jumanji, “𝐷𝑖𝑑 𝑦𝑜𝑢 𝑚𝑒𝑎𝑛 𝐽𝑢𝑚𝑜𝑛𝑗𝑖?”

A brief educational thread at the intersection of biology and pop culture… /1

With the FDA Oncology ODAC on #Myeloma MRD today, re-posting our episode on all things MRD with the MASTER Luciano J Costa!
Blood Cancer Talks Eddie Cliff Ashwin Kishtagari, MD
#mmsm #mmMRD

New work led by Mohammad Saadatagah Mohammadreza Naderian in JAMA Cardiology underscores that not all CHIP 🩸🧬 is the same. TET2 CHIP assoc'd w/ ⬆️ IL-6 and AF risk, esp when clones are large.

jamanetwork.com/journals/jamac…

Art Schuermans Alex Bick Pradeep Natarajan Iftikhar J. Kullo Christie Ballantyne

We report a case with distinct bone marrow findings associated with a noncanonical UBA1 variant (Ser56Phe) ➡️ Marked erythroid hyperplasia and cytoplasmic vacuolization.

Our case highlights the fact that UBA1 assays that test only for Met41 variants are insufficient to identify

The impact of cytotoxic therapy on the risk of progression and death in clonal cytopenia(s) of undetermined significance ashpublications.org/bloodadvances/… #TCCUS Mayo Clinic Comprehensive Cancer Center

Out now! Our newest paper on how blood stem cells retain their regenerative potential and vitality with age.

Paper link: nature.com/articles/s4155…

More info and video abstract: tinyurl.com/4u7hud78

#StemCells #Aging #Hematopoiesis

Summary below:

Can anti-aging antibodies revive the immune system? In Nature News & Views we previewed the latest breakthrough from Irv Weissman's team in @Nature that used immunotherapy to deplete aging stem cells. Yasar Arfat T Kasu nature.com/articles/d4158…

Low frequency and rare variants associated with rheumatoid arthritis
Kronzer et al. Nat Rev Rheumatol
nature.com/articles/s4158…

Tune in to our new episode on CAR T-cell therapy in early relapsed #MultipleMyeloma with Samer Al Hadidi, MD,MS,FACP! We dissect the data presented at FDA Oncology ODAC and how to make sense of it in clinical practice as we anticipate approval soon!

share.transistor.fm/s/ee835824

Congratulations Carmelo Gurnari and #maciejewski lab Cleveland Clinic
Happy to contribute PNH patients from Vanderbilt University Medical Center for this seminal work.
ashpublications.org/blood/article-…