Amin Abedini (@aminabedini1990) 's Twitter Profile
Amin Abedini

@aminabedini1990

MD | Internal Medicine Resident @UMMC
Aspirant Nephrologist & Physician-Scientist
Single-Cell RNA-Seq | Spatial Transcriptomics
Formerly @Susztaklab, @Penn

ID: 1547366823791890432

calendar_today13-07-2022 23:46:24

18 Tweet

103 Takipçi

239 Takip Edilen

Penn Medicine CSO (@pennmedcso) 's Twitter Profile Photo

Single-cell multi-omic & spatial profiling of human kidneys implicates the fibrotic microenvironment in kidney disease progression ft. Amin Abedini, Jonathan Levinsohn & Katalin Susztak (Penn Kidney/ Penn IDOM/ Penn Genetics/ Children's Hospital) Nature Genetics tinyurl.com/489kkacd

Single-cell multi-omic &amp; spatial profiling of human kidneys implicates the fibrotic microenvironment in kidney disease progression ft. <a href="/AminAbedini1990/">Amin Abedini</a>, Jonathan Levinsohn &amp; <a href="/KSusztak/">Katalin Susztak</a> (<a href="/PennKidney/">Penn Kidney</a>/ <a href="/PennIDOM/">Penn IDOM</a>/ <a href="/PennGenetics/">Penn Genetics</a>/ <a href="/ChildrensPhila/">Children's Hospital</a>) <a href="/NatureGenet/">Nature Genetics</a> tinyurl.com/489kkacd
Hao Yin (@haoyin20) 's Twitter Profile Photo

Human #Kidney #KidneyFibrosis #SpatialTranscriptomics (Visium 11 case + 4 ctrl; CosMx 1 + 1) + sc-/sn-RNAseq (n=47) + snATACseq (n=18)▶️ Fibrotic microenvironment gene signature, instead of histologic fibrosis score, predicts renal function decline (eGFR), based on kidney tubule

Human #Kidney #KidneyFibrosis
#SpatialTranscriptomics (Visium 11 case + 4 ctrl; CosMx 1 + 1)
+ sc-/sn-RNAseq (n=47)
+ snATACseq (n=18)▶️
Fibrotic microenvironment gene signature, instead of histologic fibrosis score, predicts renal function decline (eGFR), based on kidney tubule
Katalin Susztak (@ksusztak) 's Twitter Profile Photo

Kidney Cell Gene Signatures as the next generation pathologists. Nice to see our work highlighted on the front page of the September issues of ASN Kidney News lead by 2 excellent physician scientist in the lab Amin Abedini Jon Levinsohn nature.com/articles/s4158…

Kidney Cell Gene Signatures as the next generation pathologists. Nice to see our work highlighted on the front page of the September issues of <a href="/KidneyNews/">ASN Kidney News</a> lead by 2 excellent physician scientist in the lab <a href="/AminAbedini1990/">Amin Abedini</a>  Jon Levinsohn nature.com/articles/s4158…
Katalin Susztak (@ksusztak) 's Twitter Profile Photo

⁦The Susztak lab is ready to share amazing new results at the 2024 American Society of Nephrology⁩ week 🧠🧬🫘Warning: attending our talks may result in spontaneous kidney knowledge overload. Bring coffee & stay hydrated ☕️💧#KidneyWk

⁦The Susztak lab is ready to share amazing new results at the 2024 <a href="/ASNKidney/">American Society of Nephrology</a>⁩ week 🧠🧬🫘Warning: attending our talks may result in spontaneous kidney knowledge overload. Bring coffee &amp; stay hydrated ☕️💧#KidneyWk
Katalin Susztak (@ksusztak) 's Twitter Profile Photo

🚨Excited to share our @LiangXiuejie latest paper in Nature Communications! We identified #TET2 as a novel risk gene for kidney disease. By linking GWAS with single-cell and CRISPR studies, we reveal how TET2 impacts DNA repair and activates cytosolic nucleotide sensors.

Katalin Susztak (@ksusztak) 's Twitter Profile Photo

🎇Our new paper in Science Magazine: Kidney Multiome-Based Genetic Scorecard Reveals Convergent Coding and Regulatory Variants. Hongbo Liu science.org/doi/10.1126/sc… 1. Full spectrum of genetic variants related to kidney function (1,000 loci). 2. Comprehensive annotation of

Penn Medicine (@pennmedicine) 's Twitter Profile Photo

Creation of the most complete map of more than 1000 genes that influence kidney function could help experts diagnose and design targeted treatments for #kidneydisease. spr.ly/6016IZoKQ

Kidney International (@kidney_int) 's Twitter Profile Photo

When two signals cross paths: cGAS-STING and ER stress in kidney disease progression Ryo Yamada and Motoko Yanagita doi.org/10.1016/j.kint… Original article: doi.org/10.1016/j.kint… #KICommentary #MedTwitter #NephTwitter

When two signals cross paths: cGAS-STING and ER stress in kidney disease progression
Ryo Yamada and Motoko Yanagita
doi.org/10.1016/j.kint…

Original article: doi.org/10.1016/j.kint…

#KICommentary #MedTwitter #NephTwitter
ITMAT (@upenn_itmat) 's Twitter Profile Photo

Multi-population study into genetic architecture of human #KidneyFunction discovers 124 genes amenable to targeting by FDA-approved drugs doi.org/10.1126/scienc… Katalin Susztak Dr. Marylyn D. Ritchie, PhD #TranslationalScience #DrugRepurposing

Multi-population study into genetic architecture of human #KidneyFunction discovers 124 genes amenable to targeting by FDA-approved drugs doi.org/10.1126/scienc… <a href="/KSusztak/">Katalin Susztak</a> <a href="/MarylynRitchie/">Dr. Marylyn D. Ritchie, PhD</a> #TranslationalScience #DrugRepurposing
Penn Medicine CSO (@pennmedcso) 's Twitter Profile Photo

New research out in Science Magazine from Hongbo Liu & Katalin Susztak (Penn Kidney/ Penn IDOM/ Penn Genetics) provides a genetic map of kidney function & introduces a kidney multiome-based genetic scorecard for disease diagnostics & therapeutic development tinyurl.com/ubkutd4s

New research out in <a href="/ScienceMagazine/">Science Magazine</a> from <a href="/Hongbo919Liu/">Hongbo Liu</a> &amp; <a href="/KSusztak/">Katalin Susztak</a> (<a href="/PennKidney/">Penn Kidney</a>/ <a href="/PennIDOM/">Penn IDOM</a>/ <a href="/PennGenetics/">Penn Genetics</a>) provides a genetic map of kidney function &amp; introduces a kidney multiome-based genetic scorecard for disease diagnostics &amp; therapeutic development tinyurl.com/ubkutd4s
Katalin Susztak (@ksusztak) 's Twitter Profile Photo

Nice summary of our paper by Anna Kottgen ⁦Matthias Wuttke⁩ GWAS scorecard prioritizes kidney genes using coding and regulatory variants | ⁦Nature Reviews Nephrology⁩ nature.com/articles/s4158…

Katalin Susztak (@ksusztak) 's Twitter Profile Photo

Day 50 of #WhyScience 🤪🎇 Thrilled to share the preprint from one of my most talented trainees, Jon Levinsohn: "Single-Cell Spatial Mapping of Human Kidney Development Reveals the Critical Role of the Local Microenvironment in Cell Fate Decisions" Jon built a comprehensive

Day 50 of #WhyScience 🤪🎇
Thrilled to share the preprint from one of my most talented trainees, Jon Levinsohn:
"Single-Cell Spatial Mapping of Human Kidney Development Reveals the Critical Role of the Local Microenvironment in Cell Fate Decisions"
Jon built a comprehensive
Katalin Susztak (@ksusztak) 's Twitter Profile Photo

🚨 Big news from @SusztakLab! Our paper is out in Nature Genetics: "From Million-Cell Atlases to One-Patient Reports" 🧬🧑‍⚕️Together with biostats wizard @NancyRZhang and physician-scientist trainee Konstantin Klötzer, we built a cross-species single-cell kidney atlas and analytics

🚨 Big news from @SusztakLab! Our paper is out in <a href="/NatureGenet/">Nature Genetics</a>: "From Million-Cell Atlases to One-Patient Reports" 🧬🧑‍⚕️Together with biostats wizard @NancyRZhang and physician-scientist trainee <a href="/KonstantinKltz/">Konstantin Klötzer</a>, we built a cross-species single-cell kidney atlas and analytics
Katalin Susztak (@ksusztak) 's Twitter Profile Photo

My birthday is a joyful milestone. Seeing our work published is a proud achievement. Having both happen on the same day — truly unforgettable! Thank you Nature Medicine🥳 Excited to share our new study: The proteogenomic landscape of the human kidney and implications for

My birthday is a joyful milestone. Seeing our work published is a proud achievement.
Having both happen on the same day — truly unforgettable! Thank you <a href="/NatureMedicine/">Nature Medicine</a>🥳
Excited to share our new study: The proteogenomic landscape of the human kidney and implications for
Penn Medicine (@pennmedicine) 's Twitter Profile Photo

New AI tools developed by researchers in the Perelman School of Medicine and the Wharton School can analyze kidney disease at the cellular level to match the most effective treatments and speed up solutions. Katalin Susztak Penn Kidney spr.ly/6018fUoIj

New AI tools developed by researchers in the Perelman School of Medicine and the Wharton School can analyze kidney disease at the cellular level to match the most effective treatments and speed up solutions. <a href="/KSusztak/">Katalin Susztak</a> <a href="/PennKidney/">Penn Kidney</a> spr.ly/6018fUoIj
ITMAT (@upenn_itmat) 's Twitter Profile Photo

Comprehensive #Proteogenomics (pQTL) of human kidneys discerning genetically regulated protein changes in #KidneyFunction and #CardioKidneyMetabolicDisease (CKM) offer targetable mechanism nature.com/articles/s4159… Katalin Susztak #TranslationalScience

Nature Medicine (@naturemedicine) 's Twitter Profile Photo

RESEARCH Based on 337 human kidney & plasma samples, the authors generate the first kidney pQTL dataset & explore novel risk loci relevant for cardio-kidney-metabolic health. #metabolism #liver #proteomics nature.com/articles/s4159…