📢 Come join us! Tenure-track faculty opening in Computational Biology at Carnegie Mellon Ray and Stephanie Lane Computational Biology Dept.. We have two rounds of deadlines (please apply by Oct 2 or Dec 8 2022). CMU School of Computer Science has a vibrant environment & amazing students. Reach out for questions. cbd.cmu.edu/join-us/tenure…

Interesting new insights into TFs and cell fate: Arginine-methylation controls reprogramming speed of a key transcription factor! biorxiv.org/content/10.110… Gene Regulation Transcription Factors Epigenetic Hulk Centre for Genomic Regulation (CRG) Zaret Lab Max Delbrück Center

Postdoc position available! - Hanna lab (University of Cambridge) - Topic: epigenetics, placental function, pregnancy - Application deadline: 4th November - Link: jobs.cam.ac.uk/job/37346/ @CTR_Cambridge Cambridge Reproduction

Job opportunity: Postdoc position in computational biology. To be co-supervised by myself and ⁦Federico Gaiti⁩. There is still time to apply. #epigenetics #Toronto #genomic #computationalscience #cancerevolution nature.com/naturecareers/…

We have a postdoc position available. #TEs, #Trophoblast, #Epigenetics qmul.ac.uk/jobs/vacancies…

Excited to share our recent paper on application of our epigenome editing tools to tackle neurodevelopmental disease. A few points we learned are listed below. Multiplex epigenome editing of MECP2 to rescue Rett syndrome neurons science.org/doi/10.1126/sc…

Our new work assessing the role of NR5A2 and ESRRB in early mouse embryos is out: NR5A2 is essential for morula development. biorxiv.org/content/10.110…

Is there any known, published evidence of physical direct interactions between BAF (SWI/SNF) and NuRD?

UBC Life Sciences Institute is hiring 6 (!!!) new faculty members! That's right, 6! 100% hard money, great students, fabulous colleagues (like me!), and living in Vancouver. Apply! Check out the ad here lsi.ubc.ca/2023/01/27/six…

What drives cell type-specific expression differences in the cortex of Alzheimer’s patients? We used single-nucleus multiomics(ATAC+RNA) to link DEGs to candidate CREs and identify TFs that could contribute to altered regulation.🧵 cell.com/cell-genomics/… #singlecell #Alzheimers

1/ We are excited to share some news about human IRF1, which surprisingly turns out to be the key transcription factor downstream from IFN-gamma and STAT1 in macrophages (sciencedirect.com/science/articl…).

Sox2 expression can be regulated across boundaries generated by CTCF-cohesin loops dlvr.it/Shsm9w

How do cell type specific chromatin features affect binding of STAT transcription factors and gene induction during interferon response? Here comes our TRR179 study on that: doi.org/10.26508/lsa.2…

Engineering of Chinese hamster ovary cells for co-overexpressing MYC and XBP1s increased cell proliferation and recombinant EPO production dlvr.it/ShvXJY

Novel TCF7L2 familial linkage and association with Type 2 diabetes, depression, and their comorbidity dlvr.it/ShvXK3

CTCF, BEAF-32, and CP190 are not required for the establishment of TADs in early Drosophila embryos but have locus-specific roles dlvr.it/ShvzNb

A de novo transcription-dependent TAD boundary underpins critical multiway interactions during antibody class switch recombination dlvr.it/ShwgTx

Are you confused/intrigued about pioneer TFs? Interesting viewpoint discussion on pTFs by the leaders in the field: -What are pTF? -What do they do? -How to study pTF? -Can we classify pTFs? -Are they context dependent? -Does chromatin affect pTF activity? nature.com/articles/s4157…

A lab member is trying to establish a timeline for enhancer studies covering discovery, identification, activity, & enhancer-gene connectivity. Are we missing something that we must add to the timeline? Gene Regulation Transcription Factors Chromatin Haiku #epigenetics #Chromatin