Transcriptomics response conserved across critical illness of different aetiologies. A concept hopefully generalizable to a broad range of clinical problems. Data Driven Analysis Reveals Shared Transcriptome Response, ... : Critical Care Medicine journals.lww.com/ccmjournal/Ful…

I just ordered this book for my kids.

In addition to Proxima Centauri B the closest of exoplanets there is another candidate Proxima Centauri C. Only about 4 light years away! “A low-mass planet candidate orbiting Proxima Centauri at a distance of 1.5 AU | Science Advances” advances.sciencemag.org/content/6/3/ea…

Thrilled to announce publication in Nature Communications of the first locked multi-gene signature for acute #infections and #sepsis successfully validated in a blinded clinical cohort. This demonstrates the power of Inflammatix's machine learning platform! rdcu.be/b2whX

Excited to present “Learning to Simulate Complex Physics with Graph Networks”. arxiv.org/abs/2002.09405 Our model can generate realistic simulations, and generalizes to much larger systems and longer trajectories than its training. w/ @spectralhippo Rex Ying Jure Leskovec

Neurofibromatosis involves activation of the RAS pathway. Inhibition of MEK, a component of the pathway, with selumetinib was performed in 50 children with inoperable disease. A total of 70% had a response, which was maintained in the majority for more than a year.

A very stable genius is moving onto unproven combination therapy and providing a reference

These are actual images of Los Angeles before and after the shutdown. This is what we’re fighting for. Consider it a preview of what happens if we succeed against the haters. This is bigger than you or me. It’s the air we breathe & the planet we live on

Distinct regional ontogeny and activation of tumor associated macrophages in human glioblastoma disq.us/t/3st38m4 Please see our analysis of single cell expression data combined with spatial bulk expression from the Ivy Glioblastoma Atlas.

Another huge welcome to Dr. Zsolt Zador who recently joined McMaster Neurosurgery. Here he is taking the residents through an endoscopic third ventriculostomy (ETV). Welcome Zsolt Zador! Can anyone name the structures seen in this endoscopic view? #Neurosurgery

The second time a whole brain was donated at McMaster to the Singh Lab Sheila Singh Brain Tumour Lab for further #glioblastoma research. Privileged to collaborate to find regional variations in brain/GBM stiffness. This was inspired by Cindy Graham’s Cindy Graham Memorial GBM Research Endowment extremely generous gift.

The 5th edition of the WHO classification of CNS tumors is online today! Great timing with SNO 2021 meeting! tumourclassification.iarc.who.int/welcome/

We start them early - here we have Steven Qiu, medical student at McMaster, kicking off the late breaking neurotrauma abstract session at CNS with an excellent oral presentation on TBI endo types, supervised by Dr. Zador and Dr. Sharma. Congratulations Steven!

Exciting paper by William Gwynne et al published in Cancer Cell. Grateful to be part of the team contributing towards scRNA-seq analysis featured in this publication. #singlecellanalysis -selective metabolic vulnerabilities in MYC-amplified medulloblastoma cell.com/cancer-cell/pd…

Combating multidrug-resistant Gram-negative bacteria with nanotechnology nature.com/articles/nmicr…

Zsolt Zador (ACL in Neurosurgery) explains self organising maps using transformers - now I get it!